O|GlcNAcylation regulates the methionine cycle to promote ...

Methionine Metabolism Shapes T Helper Cell Responses through ...

Epigenetic modifications on DNA and histones regulate gene expression by modulating chromatin accessibility to transcription machinery.

Transient Methionine Deprivation Triggers Histone Modification and ...

Methionine metabolism regulates pluripotent stem cell ... O-GlcNAcylation regulates the methionine cycle to promote pluripotency of stem cells.

Fig. 1. AHCY is important for mESC pluripotency and self-renewal ...

S-adenosyl-homocysteine-hydrolase (AHCY) plays an important role in the methionine cycle regulating cellular methylation levels. AHCY has been reported to ...

A mitochondrial STAT3-methionine metabolism axis promotes ILC2 ...

Mitochondrial STAT3 further facilitates adenosine triphosphate synthesis to fuel the methionine cycle and generation of S-adenosylmethionine, ...

University of Dundee The role of O-GlcNAcylation in development ...

O-GlcNAcylation regulates the methionine cycle to promote · pluripotency of stem cells. Proc. Natl. Acad. Sci. USA 117, 7755-7763. doi:10. 1073/pnas ...

Regulation of Liver Regeneration by Hepatocyte O-GlcNAcylation in ...

Here, we report that O-GlcNAcylation, an intracellular post-translational modification regulated by 2 enzymes, O-GlcNAc transferase (OGT) and O- ...

Metabolic reprogramming and epigenetic modifications on the path ...

Serine and glycine regulate methylation by linking with the folate cycle, which is coupled to the methionine cycle (Fig. 2). me-THF can also be produced by the ...

Methionine cycle-dependent regulation of T cells in cancer immunity

Exogenous methionine is required during this process to support protein synthesis and generate SAM for methylation reactions required for T cell ...

Connections between metabolism and epigenetic modifications in ...

The O-GlcNAc modified HDAC1 affects gene transcription such as p21 transcription via regulating histone acetylation level, and consequently ...

Methionine deficiency facilitates antitumour immunity by ... - Gut

Objective Methionine metabolism is involved in a myriad of cellular functions, including methylation reactions and redox maintenance.

Deletion of Methionine Sulfoxide Reductase A Does Not Affect ...

ERK can also phosphorylate and activate p53, leading to cell cycle arrest. However, p53 stability is negatively regulated by methionine oxidation, thus deletion ...

Methionine - Wikipedia

Methionine plays a critical role in the metabolism and health of many species, including humans. Methionine is also involved in angiogenesis.

Methionine metabolism is essential for SIRT1‐regulated mouse ...

Here, we provide evidence that SIRT1, the most conserved mammalian NAD+‐dependent protein deacetylase, is critically involved in modulating methionine ...

S-adenosyl-l-homocysteine hydrolase links methionine metabolism ...

We show that AHCY is essential for cyclic H3K4 trimethylation, genome-wide recruitment of BMAL1 to chromatin, and subsequent circadian ...

Mechanism of CXCL8 regulation of methionine metabolism to ...

Based on transcriptome sequencing analysis, CXCL8 regulates methionine metabolic reprogramming via energy metabolism regulatory mechanisms, ...

Glycine promotes longevity in Caenorhabditis elegans in a ... - PLOS

Glycine feeds into the methionine cycle. We find that mutations in components of this cycle, methionine synthase (metr-1) and S-adenosylmethionine synthetase ( ...

Methionine coordinates a hierarchically organized anabolic program ...

Collectively, these data suggest that Gcn4p is necessary for the methionine-mediated growth in otherwise amino acid poor conditions. We ...

Folate promotes S-adenosyl methionine reactions and the microbial ...

Abstract · Introduction · Metabolism of folate · Folate deficiency and genomic instability · Methylation cycle and the potential role of folate.

Alterations of Methionine Metabolism as Potential Targets for ... - MDPI

Among them, the G-protein-coupled receptor kinase-interacting protein 1 and the MEK1/2–ERK1/2 signaling pathway (promoting colon cancer cell proliferation) are ...

Amino acid metabolism, redox balance and epigenetic regulation in ...

Amino acid metabolism might support cancer cells survival and further induce therapeutic resistance by maintaining redox homeostasis, sustaining energy ...