- Low|Frequency and Rare|Coding Variation Contributes ...🔍
- No evidence for association between polygenic risk for multiple ...🔍
- White matter microstructural differences in children and genetic risk ...🔍
- Comparing Multiple Sclerosis Age of Onset in American American ...🔍
- Polygenic risk scores🔍
- Gene|environment interactions in Multiple Sclerosis🔍
- Genetics of Multiple Sclerosis🔍
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Polygenic Multiple Sclerosis Risk and Population‐Based Childhood ...
Low-Frequency and Rare-Coding Variation Contributes ... - Cell Press
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by ...
Chapter 16 - Genetics of pediatric multiple sclerosis
MS is not a monogenic disease and thus recurrence risk data for relatives of patients are based on empiric data rather than strict theoretical models.
No evidence for association between polygenic risk for multiple ...
5 References · Polygenic Multiple Sclerosis Risk and Population‐Based Childhood Brain Imaging · Genetic susceptibility to multiple sclerosis: Brain structure and ...
White matter microstructural differences in children and genetic risk ...
CONCLUSION: Genetic risk for MS is associated with spatially distinct clusters of increased FA during childhood brain development. Original ...
Comparing Multiple Sclerosis Age of Onset in American American ...
sclerosis risk among Hispanic and African American populations living in the ... current polygenic risk scores may exacerbate health disparities [published.
Polygenic risk scores: from research tools to clinical instruments
The PRS is formed from a set of independent risk variants associated with a disorder, based on the current evidence from the largest or most ...
Gene-environment interactions in Multiple Sclerosis: a UK Biobank ...
There was strong evidence of interaction between polygenic risk for MS and childhood obesity. (PRSMHC: AP=0.17, 95% CI 0.06 - 0.25, p=0.004 ...
White matter microstructural differences in children and genetic risk ...
The MS-PRS was positively associated with the number of molehills (β = 0.9, SE = 0.29, p = 0.002). Molehills were found more often in the corpus callosum (β = ...
Genetics of Multiple Sclerosis - an overview | ScienceDirect Topics
Like many complex disorders, MS is likely to have oligo/polygenic cause and disease is likely to be an interplay between environmental and genetic factors. For ...
Polygenic risk for multiple sclerosis and multi-modal brain imaging among 8-12 year old children in the general population. Casper Louk de Mol. Casper Louk de ...
Methodologies underpinning polygenic risk scores estimation
... multiple sclerosis: classical and hypothesis-driven approaches. Hum ... population-based linkage analyses. Am J Hum Genet 81(3):559–575 ...
Evaluating genomic polygenic risk scores for childhood acute ...
Previous PRS models for ALL were based on significant loci observed in genome- wide association studies (GWASs), even though genomic PRS models have been shown ...
Integration of epigenetic and genetic profiles identifies multiple ...
Cell-specific polygenic risk scores were developed to examine the cumulative impact of the susceptibility genes on MS risk and clinical phenotypes, showing ...
Brain changes from multiple sclerosis may occur in preteens
There was a positive association noted between the MS polygenic risk scores and global fractional anisotropy. Findings showed higher fractional ...
Polygenic risk score association with multiple sclerosis susceptibility ...
Polygenic inheritance plays a pivotal role in driving multiple sclerosis susceptibility, an inflammatory demyelinating disease of the CNS.
Multiancestral polygenic risk score for pediatric asthma
To address this goal, we used an existing large- scale genome-wide association derived from diverse populations and a Bayesian framework to ...
case, 20 had multiple sclerosis (age-adjusted risk 1·79% ... This full-sibling rate mirrored that in (1) a population-based sample of 1044 multiple sclerosis ...
Attitudes among Parents towards Return of Disease-Related ... - MDPI
... Polygenic Risk Scores (PRS) for Their Children. by. Shannon Terek. Shannon Terek ... A polygenic risk score for asthma in a large racially diverse population.
Can polygenic risk scores help explain disease prevalence ...
A clear variation in GWAS-based genetic risk was observed based on ancestry and we identified populations that have a higher genetic liability ...
Association of Genetic Risk for Rheumatoid Arthritis With Cognitive ...
No equivalent associations were seen for polygenic risk associated with inflammatory bowel disease or multiple sclerosis. CONCLUSIONS AND ...