Polygenic Susceptibility to Hypertension and Blood ...

Life-Course Associations between Blood Pressure-Related ... - MDPI

The multi-ancestry genome-wide polygenic risk scores (PRSs) for systolic BP (SBP), diastolic BP (DBP), and hypertension were tested for an association with ...

polygenic risk scores predict hypertension onset and cardiovascular ...

We demonstrated that genetic information improves clinical risk prediction of hypertension. Blood pressure PRSs could be used together with traditional risk ...

Polygenic Susceptibility to Hypertension and Blood Pressure ...

Given that BP is a highly heritable trait, we hypothesize that a higher polygenic susceptibility to hypertension (PSH) leads to worse BP control in stroke ...

Polygenic Susceptibility to Hypertension is Associated with Worse ...

Hypertension is a highly heritable trait and a higher polygenic susceptibility to hypertension (PSH) is known to be associated with higher risk ...

Polygenic predisposition to hypertension predicts blood ... - YouTube

Shufan Huo, MD, PhD, Yale School of Medicine, New Haven, CT, explains her work studying the impact of polygenic predisposition to ...

Polygenic Risk Scores Predict Blood Pressure Treatment Response ...

Individuals at enhanced polygenic risk of high systolic blood pressure had increased treatment resistance risk and less pronounced response ...

Polygenic Susceptibility to Hypertension and Blood Pressure ...

Discussion A higher PSH is associated with worse BP control in stroke survivors. These findings point to genetic predisposition as an important ...

Polygenic risk scores associate with blood pressure traits across the ...

To date, the performance of BP PRSs has mainly been assessed in adults, and less is known about polygenic hypertension risk in childhood.

Polygenic Susceptibility to Hypertension and Blood ... - Amedeo Smart

Read + Share. Acosta J, Both CP, Demarais ZS, Conlon CJ, et al. Polygenic Susceptibility to Hypertension and Blood Pressure Control in Stroke Survivors.

What a Polygenic Risk Score Can and Can't Tell You

As a cardiologist, Pradeep Natarajan, MMSc '15, knows that high blood pressure, smoking, and high cholesterol raise a patient's risk of ...

Study uncovers the role of polygenic risk scores in hypertension ...

Hypertension remains a leading cause of cardiovascular disease. Genetic predispositions account for a significant portion of blood pressure ...

Dissecting the Polygenic Basis of Primary Hypertension - Frontiers

Recently, PRS associated with incident hypertension in a population based-cohort with the highest 2.5% PRS had a 2.3-fold risk of hypertension ...

Polygenic Risk Scores for Blood Pressure to Assess the Risk of ...

Genetic variants associated with essential hypertension, mainly SBP, increase the risk of severe bevacizumab-induced hypertension.

Genomics of Blood Pressure and Hypertension: Extending the ...

In this review, we leverage the burgeoning list of polygenic and monogenic variants associated with BP regulation along with phenome-wide ...

Polygenic Susceptibility to Hypertension is Associated with Worse ...

Blood pressure is a highly heritable trait, with recent analysis estimating that up to 31% of its variance can be explained by genetic variation.7 This ...

Differential Susceptibility to Hypertension Is Due to Selection during ...

In addition, we show that latitude and one of these alleles, GNB3 (G protein β3 subunit) 825T, account for a major portion of worldwide variation in blood ...

Contribution of Polygenic Risk to Hypertension Among Long-Term ...

Our results, therefore, suggest that consideration of blood pressure polygenic risk in combination with established cancer treatment–related ...

Study finds 500 new blood pressure genes - VUMC News

“Our results demonstrate that the biology of blood pressure is highly complex and polygenic, influenced by thousands of single nucleotide ...

Systolic BP Polygenic Risk Score With Chlorthalidone Response

Systolic blood pressure (SBP) polygenic risk score (PRS) was associated with SBP response to chlorthalidone, but not lisinopril, using two ...

Hypertension - Genetics - MedlinePlus

Hypertension is a key feature of some rare genetic disorders, including familial hyperaldosteronism, pseudohypoaldosteronism type 2, Liddle syndrome, and ...