Regulating the NLRP3 Inflammasome in Autoimmune Diseases

Role of NLRP3 inflammasome in systemic sclerosis

SSc, as an autoimmune disease featured by inflammation, vascular damage, and fibrosis, involves immune cells, endothelial cells (ECs), and ...

Role of the NLRP3 inflammasome in autoimmune diseases

... NLRP3 inflammasome and present the mechanisms underlying its activation and regulation. We also summarize recent studies that have reported on the roles of ...

Role of the NLRP3 inflammasome in autoimmune diseases

... NLRP3 inflammasome and present the mechanisms underlying its activation and regulation. We also summarize recent studies that have reported on the roles of ...

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune ...

It is therefore crucial to understand the biology and regulation of NLRP3 inflammasome and determine its affect in the context of various diseases. Of note, ...

Autophagy, NLRP3 inflammasome and auto-inflammatory/immune ...

NLRP3 inflammasome accounts for the pathogenesis of numerous autoina flammatory and autoimmune diseases. ... in regulating NLRP3 inflammasome activation ...

Inflammasomes and Childhood Autoimmune Diseases: A Review of ...

One of the known triggers of NLRP3 inflammasome activation in SLE is neutrophil extracellular trap (NET)-associated proteins [78]. For example, ...

HSPH researchers uncover how a key inflammatory pathway is ...

The investigators found that calcium signaling triggers mitochondrial damage to activate the NLRP3 inflammasome, which leads in turn to ...

NLRP3 Inflammasomes: Dual Function in Infectious Diseases

The NLRP3 inflammasome regulates pyroptosis by affecting its downstream production of pro–caspase-1 and pro–IL-1β, driving inflammation toward a ...

NLRP3 inflammasome induces chemotactic immune cell migration ...

The NLRP3 inflammasome is thought to be involved in the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis ( ...

Redox regulation of hepatic NLRP3 inflammasome activation and ...

Trichloroethene (TCE) exposure is associated with the development of various autoimmune diseases (ADs), including autoimmune hepatitis (AIH) ...

NLRP3 Inflammasome and MS/EAE - Inoue - Wiley Online Library

Recent studies showed that the NLRP3 inflammasome exacerbates experimental autoimmune encephalomyelitis (EAE), an animal model of MS.

Clinicopathologic Significance of Inflammasome Activation in Auto

Targeting the NLRP3 inflammasome in inflammatory diseases. ... regulates U1 small nuclear RNP immune complex- mediated activation of the NLRP3 inflammasome.

New Insights on NLRP3 Inflammasome: Mechanisms of Activation ...

Regulation of NLRP3 inflammasome ameliorates NLRP3-mediated diseases. Much effort has been invested in studying the activation, and ...

Deficient NLRP3 and AIM2 Inflammasome Function in Autoimmune ...

Inflammasomes are protein complexes that promote caspase activation, resulting in processing of IL-1β and cell death, in response to infection and cellular ...

Palmitoylation prevents sustained inflammation by limiting NLRP3 ...

As a key component of the inflammasome, NLRP3 is a critical intracellular danger sensor emerging as an important clinical target in ...

Inflammasomes in the pathophysiology of autoinflammatory ...

Dysregulation of the inflammasome is associated with the onset and progression of several autoinflammatory and autoimmune diseases, including cryopyrin- ...

Mechanisms of inflammasome activation and regulation | Journal of ...

Under resting conditions, ASC is found in the mitochondria, cytosol, and nucleus, whereas NLRP3 associates with the ER (Zhou et al., 2011).

Immunomodulation of the NLRP3 Inflammasome through Structure ...

The NLRP3 inflammasome plays a role in the inflammatory response to vaccines, in antimicrobial host defense, and in autoimmune diseases. However ...

NLRP3 inflammasome in rheumatoid arthritis pathophysiology | ITT

NLRP3 is also elevated in RA synovial tissue, as well as whole blood and CD4 T cells from RA patients with active disease. In addition, active ...

Metabolic regulators of enigmatic inflammasomes in autoimmune ...

Activation of inflammasomes, mainly NLRP3, can be modulated via GPCRs interacting with different metabolites, ions, neurotransmitters and ...