Regulation of a pentameric ligand|gated ion channel by a ...

Markov state models of proton- and pore-dependent activation in a ...

The family of pentameric ligand-gated ion channels (pLGICs), also known as Cys-loop receptors, controls electrochemical signal transduction in ...

Probing solution structure of the pentameric ligand-gated ion ...

Pentameric ligand-gated ion channels undergo subtle conformational cycling to control electrochemical signal transduction in many kingdoms of ...

Chasing the open-state structure of pentameric ligand-gated ion ...

In the case of the superfamily of nicotinic-receptor channels (also referred to as pentameric ligand-gated ion channels [pLGICs]), for example, two different ...

The Free Energy Landscape of GABA Binding to a Pentameric ...

Pentameric ligand-gated ion channels (pLGICs) of the Cys-loop superfamily are important neuroreceptors that mediate fast synaptic ...

Signal Transduction at the Domain Interface of Prokaryotic ... - PLOS

Pentameric ligand-gated ion channels are activated by the binding of agonists to a site distant from the ion conduction path.

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion ...

135 References · Direct binding of phosphatidylglycerol at specific sites modulates desensitization of a ligand-gated ion channel · Regulation of a pentameric ...

The Evolution of Pentameric Ligand-Gated Ion Channels

It is becoming increasingly clear that the adaptability of a single neurotransmitter receptor superfamily, the pentameric ligand-gated ion channels (pLGICs), ...

A chimeric prokaryotic pentameric ligand–gated channel reveals ...

Recent high resolution structures of several pentameric ligand–gated ion channels have provided unprecedented details of their molecular ...

Structural Sensitivity of a Prokaryotic Pentameric Ligand-gated Ion ...

The homologous prokaryotic pentameric ligand-gated ion channel, Gloebacter ligand-gated ion channel (GLIC), represents an excellent model for probing the ...

Regulation of a pentameric ligand-gated ion channel by a ... - Lirias

Regulation of a pentameric ligand-gated ion channel by a semiconserved cationic lipid-binding site. Received for publication, March 23, 2021, and in revised ...

Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC ...

The eukaryotic pentameric ligand-gated ion channels (pLGICs), also known as Cys-loop receptors, are involved in rapid synaptic transmission in ...

Evolution of Pentameric Ligand-Gated Ion Channels: Pro-Loop ...

A new inventory and phylogenetic analysis of pLGIC genes across all kingdoms of life suggests new hypotheses on the evolutionary history of the superfamily, ...

The Pentameric Ligand-Gated Ion Channel Family: A New Member ...

In this report we present seven lines of bioinformatic evidence supporting the conclusion that the Pentameric Ligand-gated Ion Channel (pLIC) Family is a ...

(PDF) Allosteric regulation of pentameric ligand-gated ion channels

Pentameric ligand-gated ion channels (pLGICs) play a central role in intercellular communications in the nervous system by converting the ...

Ligand-gated ion channel - Wikipedia

Ligand-gated ion channels (LICs, LGIC), also commonly referred to as ionotropic receptors, are a group of transmembrane ion-channel proteins which open to ...

Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion ...

Polyunsaturated fatty acids (PUFAs) inhibit pentameric ligand-gated ion channels (pLGICs) but the mechanism of inhibition is not well ...

Atomic structure and dynamics of pentameric ligand‐gated ion ...

Pentameric ligand-gated ion channels (pLGICs) are widely expressed in the animal kingdom and are key players of neurotransmission by acetylcholine (ACh), γ- ...

Ligand-gated ion channels

Ligand-gated ion channels (LGICs) are integral membrane proteins that contain a pore which allows the regulated flow of selected ions across the plasma ...

Study elucidates mechanism of lipid regulation of ion channels

In this study, titled “Open-channel structure of a pentameric ligand-gated ion channel reveals a mechanism of leaflet-specific phospholipid ...

A chimeric prokaryotic pentameric ligand–gated channel reveals ...

Recent high resolution structures of several pentameric ligand–gated ion channels have provided unprecedented details of their molecular ...