Regulation of tissue iron homeostasis

Gateways of cellular and systemic iron homeostasis

Hepcidin, the iron-regulatory protein produced by hepatocytes, controls the flow of iron into the plasma by binding to ferroportin (on enterocytes, macrophages, ...

Iron homeostasis: a new job for macrophages in adipose tissue?

Metabolic tissues such as pancreas, liver, and adipose tissue (AT), as well as the immune cells resident in these tissues, may be involved. Recent studies ...

Iron Availability in Tissue Microenvironment: The Key Role of ... - MDPI

In recent years, increasing evidence has emerged to indicate that, in addition to its role in systemic iron metabolism, FPN may play an important function in ...

The Control of Iron Homeostasis: microRNAS Join the Party

The increase in hepcidin would then lead to down-regulation of ferroportin on cells, reduced iron absorption and recycling, and eventual iron deficiency. It ...

Tissue‐Specific Regulation of Ferroportin in Wild‐Type and Hjv

Hepcidin is a liver‐derived peptide hormone that limits iron egress from tissues to the bloodstream. It operates by binding to the iron exporter ferroportin ...

The Role of Iron Regulation in Immunometabolism and Immune ...

Importantly various immune cells regulate iron metabolism to induce their various effector functions. ... Regulation of iron homeostasis by the hypoxia ...

REGULATION OF IRON METABOLISM - Annual Reviews

In contrast, cellular iron efflux involves the sole known iron exporter ferroportin, highly expressed in duodenal cells, hepatocytes, macrophages, and placental ...

The liver in regulation of iron homeostasis

Erythropoiesis uses a major portion of the body iron to produce new red blood cells (RBCs), and, hence, it forms another critical component of the machinery.

Macrophages and Systemic Iron Homeostasis - Karger Publishers

The absorption of dietary iron, its release from stores and the plasma iron concentration are subject to regulation by the iron hormone hepcidin ...

Regulation of systemic iron homeostasis: how the body responds to ...

The iron that is required to meet the metabolic needs of cells and tissues is derived from the plasma. Plasma iron in turn reflects the ...

Iron homeostasis: An anthropocentric perspective

The regulation of iron metabolism in biological systems centers on providing adequate iron for cellular function while limiting iron toxicity.

Modelling Systemic Iron Regulation during Dietary Iron Overload ...

In contrast, ferroportin regulation by hepcidin is the predominant mechanism of iron homeostasis in response to changing iron diets for a big range of dietary ...

Iron regulatory protein (IRP)–mediated iron homeostasis is critical ...

Hepcidin reduces the release of iron into the plasma from iron exporting cells by binding to and inhibiting the iron exporter ferroportin (FPN; ...

Cardiac ferroportin regulates cellular iron homeostasis and ... - PNAS

The iron-exporting protein ferroportin is recognized as central to systemic iron regulation, but its role in tissues other than those involved in iron ...

Iron homeostasis: transport, metabolism, and regulation

Iron homeostasis: transport, metabolism, and regulation. Guo Shanshan ... cellular function and many diseases result from disturbances in iron homeostasis.

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron ...

IRP1, therefore, is needed for full regulation of iron metabolism in a few specific tissues, whereas in other tissues, IRP2 alone is sufficient for the ...

Iron Homeostasis in Health and Disease - IRIS

In particular, the importance of tissue iron accumulation in inflammation and infection, cancer, genetic, cardiovascular and neurodegenerative ...

Orchestration of Iron Homeostasis | New England Journal of Medicine

The number of newly identified genes participating in the regulation of iron homeostasis has increased at a remarkable pace.

Regulation of Iron Metabolism by Hepcidin - Annual Reviews

Hepcidin controls plasma iron concentration and tissue distribution of iron by inhibiting intestinal iron absorption, iron recycling by macrophages, and iron ...

REGULATION OF IRON HOMEOSTASIS - YouTube

This Lecture captures the processes that are involved in regulating iron absorption and maintenance of iron balance in the system.