Reprogramming of host energy metabolism mediated by the TNF ...

A Breakdown in Metabolic Reprogramming Causes Microglia ...

The mTOR pathway regulates glucose metabolism as part of a mechanism for sensing the energy status of the cell. In this pathway, AKT acts as a ...

Metabolic reprogramming of Salmonella infected macrophages and ...

Recent data provide evidence for metabolic re-programming of immune cells including macrophages during infection which is centrally controlled by mTOR.

Metabolic reprogramming in liver fibrosis - Cell Press

These metabolic adaptations are crucial for inflammatory and fibrogenic activation of macrophages, lymphoid cells, and hepatic stellate cells.

The cancer metabolic reprogramming and immune response

Energy metabolism reprogramming, which fuels fast cell growth and proliferation by adjustments of energy metabolism, has been considered as an ...

Metabolic Reprogramming in Gastric Cancer: Trojan Horse Effect

MiR-149 links IL-6 to mediate the crosstalk between tumor cells and CAFs, leading to the enhanced epithelial-to-mesenchymal transition and stem- ...

TNF in Human Tuberculosis: A Double-Edged Sword

Metabolic reprogramming occurs in alveolar and bone marrow–derived macrophages during Mtb infection (51). Alveolar macrophages have a limited ...

Cellular senescence and metabolic reprogramming: Unraveling the ...

Senescent cells mediate an increase in tricarboxylic acid cycle metabolites that play multiple roles in the microenvironment, including ...

Postbiotic Impact on Host Metabolism and Immunity Provides ...

Postbiotics that activate NOD1 (such as Tri-DAP and iE-DAP) lower insulin-stimulated glucose uptake and promote insulin resistance by increasing stress kinase ...

Metabolic flux in macrophages in obesity and type-2 diabetes

The released TNF- α in turn promotes the secretion of FFAs and inflammatory changes in adipocytes [69]. To further support this, TLR4-deletion ...

Metabolic Reprogramming in Immune Response and Tissue ...

We summarize 2 major features of metabolic reprogramming in inflammatory stages in innate and adaptive immune cells: (1) energy production and biosynthesis ...

Energy metabolism as the hub of advanced non-small cell lung ...

Among the identified energy reprogramming, mitochondrial trifunctional protein (MTP) plays an important role in FAO [140]. Viperin-mediated ...

Metabolic reprogramming in sepsis-mediated inflammation | JIR

Metabolic Regulation in Hyperinflammation ... Hyperinflammation occurs during the early stage of sepsis, damaging host organs, tissues, and cells.

IRF3 reduces adipose thermogenesis via ISG15-mediated ...

IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis. Yan, Shuai, Manju Kumari, Haopeng Xiao, Christopher Jacobs, ...

Short-Chain Fatty Acids and Human Health: From Metabolic ... - MDPI

Furthermore, research indicates that acetate can positively modulate host energy and substrate metabolism ... Metabolic Reprogramming. Mol. Cell Proteom ...

Cellular metabolism hijacked by viruses for immunoevasion - Frontiers

SARS-CoV-2 infection induces metabolic reprogramming of tryptophan toward the kynurenine pathway, which regulates host inflammation and immunity (119).

Metabolic substrate utilization in stress-induced immune cells

These functional changes require continuous metabolic adaption in order to sustain ATP homeostasis for sufficient host defense. The bioenergetic ...

Fatty Acids and NLRP3 Inflammasome–Mediated Inflammation in ...

Importantly, although numerous signaling pathways are known to integrate metabolic and inflammatory processes, the nucleotide-binding and ...

The Emerging “Hallmarks” of Metabolic Reprogramming and ...

These involve suppressing the adaptive immune response at the level of antigen presentation through promotion of expansion of immunosuppressive myeloid-derived ...

The role of lipid metabolic reprogramming in tumor microenvironment

Metabolic reprogramming is one of the 14 important hallmarks of tumorigenesis in which the energy metabolism network of tumor cells is reset to support their ...

Full article: Oxygen and metabolic reprogramming in the tumor ...

... host. Clinically the ... Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation.