Reshaping of the tumor microenvironment by cellular senescence

Cellular Senescence: Aging, Cancer, and Injury

By means of the SASP, senescent cells can influence the tissue microenvironment via paracrine mechanisms (92). They can influence neighboring proliferating ...

The Role of Senescence in Crafting Cancer-Friendly ... - Healthspan

Diving deeper into the cellular level, a significant focus of scientific inquiry has been on senescent fibroblasts. One of the groundbreaking findings from ...

Understanding and Targeting Cellular Senescence

Senescent cells, characterized by the expression of HMGA2, CDKN2A, and uPAR markers, are enriched among tumor cells (PanCK+ cells). Senescent tumor cells show ...

Cellular senescence in cancer: clinical detection and prognostic ...

Cellular senescence is also considered as a crucial endogenous tumor suppressor mechanism. In this context, senescent cells have been identified ...

Cellular Senescence Is Immunogenic and Promotes Antitumor ...

Therapy-induced senescence renders cancer cells highly immunogenic, making them very efficient in triggering protective CD8-dependent antitumor immune.

The Potent and Paradoxical Biology of Cellular Senescence in Cancer

Cellular senescence is a tumor-suppressive program that promotes tissue homeostasis by identifying damaged cells for immune-mediated clearance.

Possibility of inducing tumor cell senescence during therapy (Review)

Cellular senescence may inhibit the occurrence and development of tumors, serving as an innovative strategy for the treatment of cancer.

Cellular senescence: Neither irreversible nor reversible

Cellular senescence is a critical stress response program implicated in embryonic development, wound healing, aging, and immunity.

Senescence and Immunoregulation in the Tumor Microenvironment

Understanding the multitude of cell types present in the TME, including senescent stroma, will aid in the development of combinatorial ...

cGAS is essential for cellular senescence - PNAS

The DNA damage response is a key event leading to senescence, which is characterized by the senescence-associated secretory phenotype (SASP) ...

Unraveling the nexus between cellular senescence and malignant ...

In conclusion, understanding the links between cellular senescence and malignant transformation has led to a paradigm shift in cancer research, ...

Suppression of p16 alleviates the senescence-associated secretory ...

... senescent and tumor microenvironment ... Cellular senescence in cancer and aging. Cell. 2007; 130:223–33. https://doi ...

The right time for senescence - eLife

The SASP of senescent tumour cells modulates the tumour microenvironment, which is also composed of non-senescent proliferating tumour cells ...

Cellular senescence and nanoparticle-based therapies - De Gruyter

Cell enlargement is caused by cell cycle arrest at certain time points during cell growth [7]. For example, the size of cancer cell lines before ...

Cancer‑associated fibroblasts under therapy‑induced senescence in ...

Therapy‑induced senescence may impair cancer cell activity and compromise treatment responsiveness. CAFs and SASP are well‑studied in the ...

Cellular Senescence Promotes Adverse Effects of Chemotherapy ...

Many chemotherapeutic drugs alter cellular states, including the induction of senescence, in cancer cells and the tumor microenvironment (9, 10). Therapy- ...

Cellular senescence and the senescent secretory phenotype - JCI

These insults activate the p53 and p16INK4a tumor suppressor pathways and potentially other pathways that initiate a senescence response. Once initiated, ...

Mapping the secretory phenotype of senescent colon fibroblasts

Like programmed cell death (apoptosis), senescence is a built-in tumor suppressor mechanism that can be activated when a cell suffers an ...

Targeting cellular senescence in cancer and aging: roles of p53 and ...

Targeting senescent cells by means of removal, modulation of SASP or through cellular reprogramming represents a novel therapeutic avenue for treating cancer- ...

Cellular Senescence: Mechanisms, Morphology, and Mouse Models

Cellular senescence is a cell cycle arrest in damaged or aged cells. Although this represents a critical mechanism of tumor suppression.