Review Mitochondrial dysfunction in amyotrophic lateral sclerosis

Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis - HAL

Mitochondria, which play crucial roles in excitotoxicity, apoptosis and cell survival, have shown to be an early target in ALS pathogenesis and contribute to ...

Mitochondrial dysfunction in amyotrophic lateral sclerosis – a valid ...

In this review, we provide an update of recent advances in understanding mitochondrial biology in the pathogenesis of ALS and highlight the therapeutic value.

Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis ...

Mitochondrial dysfunction occurs in numerous neurodegenerative diseases, particularly amyotrophic lateral sclerosis (ALS), ...

Mitochondrial dysfunction in amyotrophic lateral sclerosis

The etiology of motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains to be better understood. Based on the studies from ALS patients and ...

Oxidative stress is an essential feature of ALS muscle pathology (reviewed by Loeffler et al, 2016) 31. Oxidative stress caused by excessive mitochondrial ROS ...

Mitochondria in Amyotrophic Lateral Sclerosis: A Trigger and a Target

Abstract. Strong evidence shows that mitochondrial dysfunction is involved in amyotrophic lateral sclerosis (ALS), but despite the fact that ...

Mitochondria in amyotrophic lateral sclerosis: a trigger and a target.

On the other hand, mitochondrial dysfunction in ALS does not seem to be restricted only to motor neurons as it is also present in other tissues, particularly ...

Rare and common genetic determinants of mitochondrial function ...

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving selective vulnerability of energy-intensive motor neurons (MNs).

Mitochondria Dysfunction in Frontotemporal Dementia/Amyotrophic ...

In this review, we discuss how mutations associated with FTD/ALS disrupt mitochondrial function, and we review how the use of Drosophila models ...

The Role of Mitochondria in Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is a prevalent feature of many neurodegenerative diseases including motor neuron disorders such as amyotrophic lateral sclerosis (ALS ...

The Impact of Mitochondrial Dysfunction in Amyotrophic Lateral ...

Discover this 2022 paper in Cells by Zhao, Jiantao; Wang, Xuemei; Huo, Zijun; et. al. Abstract: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive ...

Progress in the study of mitochondrial dysfunction in pathogenesis ...

The abnormally released mitochondrial DNA will induce cellular inflammation. These phenomena may explain the loss of motor neurons in ALS patients. As a quality ...

Mitochondrial Dysfunction is a Converging Point of Multiple ...

Mitochondria have shown to be an early target in ALS pathogenesis and contribute to the disease progression. Morphological and functional defects in ...

Protein Misfolding and Mitochondrial Dysfunction in ALS Pathogenesis

The findings entitled, “SOD1 misplacing and mitochondrial dysfunction in amyotrophic lateral sclerosis pathogenesis“, published in Frontiers in ...

Mitochondrial Dysfunction is a Converging Point of Multiple ...

Mitochondria have shown to be an early target in ALS pathogenesis and contribute to the disease progression. Morphological and functional ...

Pathological Interaction between DNA Repair and Mitochondrial ...

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the degeneration of cortical and spinal cord motor neurons.

The role of mitochondria in amyotrophic lateral sclerosis

Mitochondrial dysfunction is one of the earliest pathophysiological events in amyotrophic lateral sclerosis (ALS) ... review the alterations in ...

Mitochondrial dysfunction and its role in motor neuron degeneration ...

Morphological and biochemical mitochondrial abnormalities have been described in sporadic human ALS cases, but the implications of these ...

Mitochondrial function determines severity but not risk of ... - bioRxiv

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Selective vulnerability of energy-intensive motor neurons (MNs) ...

[PDF] Mitochondrial quality control in amyotrophic lateral sclerosis

This review highlights how ineffective mitochondrial quality control may render motor neurons defenseless towards the accumulating mitochondrial damage in ...