Role of EphA4 in Mediating Motor Neuron Death in MND
Special Issue : Eph Receptors and Ephrins - IJMS - MDPI
Motor neuron disease (MND) comprises a group of fatal neurodegenerative diseases with no effective cure. As progressive motor neuron cell death is one of ...
Andrew Boyd | The University of Queensland, Australia - Academia ...
Role of EphA4 in Mediating Motor Neuron Death in MND. International Journal of Molecular Sciences. Motor neuron disease (MND) comprises a group of fatal ...
Motor Neuron Disease - MalaCards
MNDs are classified according to whether the loss of function is due to a genetic mutation (inherited) or sporadic (no family history); and whether they ...
Reduction of ephrin-A5 aggravates disease progression in ...
EphA4 genetic inhibition rescued the motor neuron phenotype in zebrafish and a rodent model of ALS. Preventing ligands from binding to the EphA4 ...
Acute Delivery of EphA4-Fc Improves Functional Recovery after ...
Role of EphA4 in Mediating Motor Neuron. Death in MND. International Journal ... 20⒕ EphA4 Activation of c-Abl Mediates Synaptic Loss and LTP Blockade.
Professor Dame Pamela J Shaw - University of Sheffield
Pamela Shaw is an academic neurologist and a world-leading researcher in motor neuron disease (MND). ... EphA4 targeting agents protect motor neurons from cell ...
Advances in molecular pathology, diagnosis, and treatment of ...
As the most common cause of adult onset motor neuron disease (MND) ... muscle weakness and may be more sensitive to detect early motor neuron loss.
Glia | Neurobiology Journal | Wiley Online Library
Specifically, the EphB1 pathway was identified to be involved in mediating neuroprotective astrocyte reactivity to injured motor neurons through ...
Pathology of Amyotrophic Lateral Sclerosis - ScienceDirect.com
The differentiation of iPSC containing an expanded C9orf72 hexanucleotide repeat into motor neurons led to elevated cell death, abnormal protein aggregation, ...
European multidisciplinary ALS network identification to cure motor ...
... motor neuron death. 16) To perform a morpholino-based genetic screen of the ... EphA4 allele slows motor neuron degeneration. To evaluate the ...
Full article: The genetic basis of amyotrophic lateral sclerosis
The convergence of the resulting effects within multiple cell types ultimately results in motor axonal retraction and motor neuronal death. There is ample ...
Zebrafish models of human motor neuron diseases - Digital CSIC
EPHA4 expression inversely correlates with disease onset and survival, and loss of function mutations in EPHA4 are associated with long survival (Van Hoecke ...
Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to ...
Motor neuron death in ALS is often attributed to apoptosis, but ... The relationships between motor neuron length and motor function, and motor ...
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron ...
Riluzole for amyotrophic lateral sclerosis (ALS)/motor neuron disease (MND) ... JDM provided substantive help with this update before his death in ...
PDB 2wo3 citation summary ‹ Protein Data Bank in Europe (PDBe ...
Role of EphA4 in Mediating Motor Neuron Death in MND. Zhao J, Stevens CH, Boyd AW, Ooi L, Bartlett PF. Int J Mol Sci 22 9430 (2021). Articles citing this ...
Fishing for causes and cures of motor neuron disorders
Overexpression of progranulin, whose loss of function (by nonsense-mediated decay) causes fronto- temporal lobar degeneration, rescued the shortened motor ...
Emeritus Professor Perry Bartlett - Queensland Brain Institute
Role of EphA4 in mediating motor neuron death in MND. International Journal of Molecular Sciences, 22 (17) 9430, 9430. doi: 10.3390/ijms22179430. Blackmore ...
Translating biological findings into new treatment strategies ... - CORE
Amyotrophic lateral sclerosis (ALS) is characterized by the selective death of motor neurons in the motor cortex, brainstem and spinal cord.
Emerging mechanisms of molecular pathology in ALS - JCI
It is plausible that reduced EphA4 activity through reduced expression or loss-of-function mutations enhances axonal outgrowth in response to injury. It is also ...
High-Content Analysis of Proapoptotic EphA4 Dependence ...
EphA4 has recently been identified as a dependence receptor that may have important functions in conditions as disparate as cancer biology and CNS injury and ...