- Trained Immunity or Tolerance🔍
- Trained immunity🔍
- Trained Immunity🔍
- Trained Innate Immunity🔍
- induction of trained immunity by COVID|19 adenoviral vaccines🔍
- Trained immunity as a novel therapeutic strategy🔍
- High|throughput screen identifies non inflammatory small molecule ...🔍
- Therapeutic targeting of trained immunity🔍
Small molecules induce trained immunity
Trained Immunity or Tolerance: Opposing Functional Programs ...
Trained immunity and tolerance are two distinct and opposing functional programs induced by the specific microbial ligands engaging the monocytes.
Trained immunity: adaptation within innate immune mechanisms
Certain microbial stimuli and endogenous ligands provoke durable changes in the function of innate immune cells that induce increased responsiveness upon ...
Trained Immunity | Arteriosclerosis, Thrombosis, and Vascular Biology
Trained immunity describes the memory characteristics of innate immune cells mediated by unique epigenetic changes and metabolic reprogramming.
Trained immunity: A Yin‐Yang balance - Wiley Online Library
In humans, BCG vaccination induced long-term immunophenotypic changes in neutrophils and increased neutrophil-dependent antimicrobial activity ...
Trained Innate Immunity, Epigenetics, and Covid-19
Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in ...
induction of trained immunity by COVID-19 adenoviral vaccines - JCI
Moreover, monocyte membrane expression of activation markers and costimulatory molecules, such as HLA-DR, CD40, and CD80, was also enhanced for ...
Trained immunity as a novel therapeutic strategy - Semantic Scholar
... small molecules, like those achieved by reverse vaccinology. Expand. 176 ... Immunometabolic changes of β-glucan-trained immunity induction and inhibition on ...
High-throughput screen identifies non inflammatory small molecule ...
We identified over two dozen small molecules in several chemical classes that induce a training phenotype in the absence of initial immune activation—a current ...
4. Promoting trained immunity. The smallest molecular structure capable of inducing an NOD2-dependent immune response is MDP. MDP is a ...
Retraining Immunity: Small Molecules Offer New Disease Defense
In a recent study, the team identified several small molecule compounds capable of inducing "trained immunity" - a phenomenon where the innate ...
Metabolic Regulation in the Induction of Trained Immunity
Specifically, targeting the metabolic programs of innate immune cells is an emerging strategy for clinical interventions, either to boost immune ...
The mechanisms and cross-protection of trained innate immunity
The induction of trained innate immunity can also polarize innate immune cells towards a hyperresponsive phenotype in the tumor microenvironment ...
Trained Immunity as an Adaptive Branch of Innate Immunity - MDPI
Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells.
First small molecules designed to stimulate immune cells against ...
The small molecule developed by the Hollings team inhibits the enzyme activity of CD38, an immunomodulating protein that can be found on natural ...
Epigenetic and Transcriptional Regulation of Innate Immunity in ...
The molecular basis of trained immunity is only partially understood, but it is clearly regulated by transcriptional and epigenetic reprogramming, involving ...
Pritzker School of Molecular Engineering on X: "Researchers in the ...
Pritzker School of Molecular Engineering have found several small molecule candidates that induce trained immunity without the potential ...
Long-Term Adaptation in Innate Immune Responses - AHA Journals
The molecular mechanisms of trained immunity are orchestrated by unique ... echolamines induce trained immunity in monocytes in vitro and in vivo. Circ.
Trained Immunity | Esser-Kahn Lab
Novel small molecule inducers may trigger trained immunity through previously unknown pathways that result in similar epigenetic and metabolic effects as BCG ...
Innate immune memory in cardiometabolic disease - Oxford Academic
Knowledge of the specific immune cells and the distinct intracellular molecular pathways involved in the induction of trained immunity will ...
In Vitro Experimental Model of Trained Innate Immunity in Human ...
Trained immunity was assessed in terms of the secondary cytokine response, the production of reactive oxygen species, cell morphology, and ...