Study Identifies Factors in Clonal Evolution of Chemotherapy ...

Clonal evolutionary analysis of cancer - Genevia Technologies

Note: Defining the basic concepts of tumor evolution builds on certain reasonable assumptions. It pays to think of cases where they may not hold ...

Clonal evolution in primary breast cancers under sequential ...

Sequential epirubicin and docetaxel monotherapy caused profound redistribution of smaller subclones in primary breast cancer.

(PDF) Clonal evolution of hematopoietic stem cells after cancer ...

Our findings suggest that cancer chemotherapy promotes an oligoclonal architecture with multiple HSPC clones possessing competing leukemic ...

Chemotherapy drives treatment resistance in bladder cancer

Study Identifies Factors in Clonal Evolution of Chemotherapy-Resistant Urothelial Carcinoma - ASCO Post. Related Stories. Bringing bladder ...

Clonal dominance defines metastatic dissemination in pancreatic ...

The shifting over time of the subclonal landscape is termed “clonal evolution,” and it is one of the fundamental mechanisms that drive tumor ...

Distinct landscape and clinical implications of therapy-related clonal ...

Therapy-related clonal hematopoiesis (t-CH) is defined as clonal hematopoiesis detected in individuals previously treated with chemotherapy and/or radiation ...

Clonal Evolution of High-Risk Chronic Lymphocytic Leukemia

Examples of subclonal CLL drivers include mutations within ATM, SF3B1, TP53 and BIRC3. In addition to genomic analyses, transcriptome profiling studies (e.g. ...

Intra-tumor heterogeneity: lessons from microbial evolution and ...

In particular, experimental evolution studies of microbial populations, which exist as clonal ... identify factors that drive or suppress ...

Mutational Characteristics of Chemotherapy-Treated Bladder ...

Study Identifies Factors in Clonal Evolution of Chemotherapy-Resistant Urothelial Carcinoma. In a study reported in Nature Genetics, Bishoy M.

Clonal Hematopoiesis of Indeterminate Potential (CHIP) Clinic

... chemotherapy or radiation therapy for cancer, or due to other factors such as inflammation or toxic exposures. Having CHIP can put you at risk for a range ...

Causes of Clonal Hematopoiesis: a Review - DigitalCommons@TMC

Recent Findings—Studies have identified multiple potential causes of CH mutations including smoking, cancer therapies, cardiometabolic disease, inflammation, ...

USC study identifies new risk factor for most common childhood ...

According the research, children genetically predisposed to overproduce lymphocytes in relation to other white blood cells are at higher ...

Clonal Hematopoiesis in Patients With Cancer: How Much Should ...

Anticancer therapies such as chemotherapy and radiotherapy are promoting factors for CHIP, in particular, for clones harboring DNA damage ...

Evolutionary landscape of clonal hematopoiesis in ... - Cell Press

Traditional cancer risk factors do not determine clonal dynamics. The ... Unfortunately, the size of the dataset did not allow us to study the ...

Genetic mechanisms of primary chemotherapy resistance ... - bioRxiv

Comparison of specimens before and after chemotherapy revealed distinct and invariant gene expression programs. While exhibiting overt therapy ...

Identifying predictive factors of chemotherapy-induced nausea and ...

Lessons from hereditary colorectal cancer. Cell 1996; 87: 159–170. 5. Nowell PC. The clonal evolution of tumor cell populations. Science.

Circulating tumor DNA - Cancer Research and Treatment

We sequenced DNA from cell-free plasma that was serially obtained from newly diagnosed FL patients undergoing systemic immunochemotherapy. The mutation profiles ...

Clonal Evolution and Therapeutic Resistance in Solid Tumors

Our work has identified examples of clonal resistance to effective therapies. This includes androgen withdrawal in advanced prostate cancer. In addition we ...

Acute Myeloid Leukemia Following Myeloproliferative Neoplasms

Their results suggested that mutations in TP53, DNA methylation and transcription factors were simultaneous with an evolution to AML. In ...

Molecular Determinants of Chemotherapy Resistance in Ovarian ...

Similar studies in ovarian cancer are needed to fully understand how chemotherapy shapes the evolution of cancer subclones and the extent to which clonal.