Telomeres and cell senescence

Telomeric aging: mitotic clock or stress indicator? - Frontiers

Cellular senescence (a state of irreversible cell cycle arrest) occurring in response to a telomere shortening may be regulated by immune surveillance. In this ...

DNA damage in telomeres and mitochondria during cellular ...

Abstract. Cellular senescence is the ultimate and irreversible loss of replicative capacity occurring in primary somatic cell culture. It is triggered as a.

Cell senescence and telomere shortening induced by a new ... - PNAS

We have identified by Fluorescence Resonance Energy Transfer a new series of quinoline-based G-quadruplex ligands that also exhibit potent and specific anti- ...

Short telomeres correlate with a strong induction of cellular ...

Interestingly, telomere lengths of both cell lines were nearly unchanged after induction of senescence. Gene expression analyses with genes ...

Senescence And Aging - MCAT Content - Jack Westin

Cells that undergo cell division shorten their telomeres because most somatic cells do not make telomerase. This means that telomere shortening is associated ...

Telomeres, cell senescence and human ageing - Wiley Online Library

Short, uncapped telomeres activate replicative senescence, an irreversible cell cycle arrest and are thus a major cause of cell ageing in vitro.

Telomere shortening as a hallmark of stem cell senescence - Fathi

This review focuses on prevalent knowledge about the mechanisms of stem cell senescence by telomere shortening and the molecular mechanism details involved in ...

Telomeres, stem cells, senescence, and cancer - JCI

In this Perspective, we will discuss these tumor suppressor mechanisms and the hypothesis that their anticancer roles come at the cost of a decline in stem ...

Shortening of Telomere Length and Replicative Cell Senescence

Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes ...

Role of Telomeres and Telomerase in Aging and Cancer

A hallmark of advanced malignancies is the ability for continuous cell divisions that almost universally correlates with the stabilization of telomere length by ...

Telomeres and Senescence: Ending the Debate - Science

In a second apparent discrepancy, senescent human cells do not lose all telomeric DNA but carry residual telomeres similar in length to those of many other ...

Molecular Aspects of Senescence and Organismal Ageing—DNA ...

... telomere shortening during cell division. When left unresolved, it may lead to the activation of senescence. Senescent cells secrete certain proteins in ...

Telomeres and Aging | Physiological Reviews

Telomeres play a central role in cell fate and aging by adjusting the cellular response to stress and growth stimulation on the basis of previous cell ...

Telomere extension turns back aging clock in cultured human cells ...

The researchers found that as few as three applications of the modified RNA over a period of a few days could significantly increase the length ...

Telomerase and the Aging Cell: Implications for Human Health

Telomeres not only shorten with cell aging, but relengthening the telomere appears to reset gene expression (as measured by expression of β-galactosidase, an ...

Telomeres and Cellular Senescence in Metabolic and Endocrine ...

It has been reported that obesity, type 2 diabetes mellitus (T2DM), NAFLD, and hypertension were associated with shortened telomere length.

Telomeres and Cell Senescence - Size Matters Not

Telomeres and Cell Senescence - Size Matters Not. Lookup NU author(s): Stella Victorelli, Dr Joao Passos. Downloads. Published version [.pdf]. Licence. This ...

Telomeres and cell homeostasis in aging - Mayo Clinic

Telomere shortening and damage are recognized as the causes of cellular senescence. Here, we describe the role of telomeres during senescence, ...

Cellular senescence, telomere recombination and maintenance

Abstract. Cellular senescence can be activated by various types of stressful stimuli, including telomere shortening, oncogenic or tumor ...

Quantitative theory of telomere length regulation and cellular ... - PNAS

This progressive shortening is associated with cellular senescence and apoptosis. Germ cells, stem cells, and the majority of cancer cells ...