The RET proto|oncogene in human cancers

... RET expression on patient outcome in human breast cancer. METHODS: We ... carcinoma (MTC) for mutations of the RET proto-oncogene. These included ...

THE ROLE OF THE ret PROTO-ONCOGENE IN HUMAN DISEASE

MEN 2A and MEN 2B are autosomal dominant cancer syndromes involving medullary thy- roid carcinoma and pheochromocytoma. In addition to these tumors, 10-20% of ...

RET Proto-Oncogene: A Review and Update of Genotype ...

RET Proto-Oncogene: A Review and Update of Genotype–Phenotype Correlations in Hereditary Medullary Thyroid Cancer and Associated Endocrine Tumors · Metrics ...

RET Proto-Oncogene Testing - Medical Clinical Policy Bulletins

RET proto-oncogene tests may also be used to distinguish sporadic tumors from familial cancers in patients with MTC but without a previous family history of ...

Jhiang SMThe RET proto-oncogene in human cancers. Oncogene 19

In a study that sequenced 39 different histological types and a total of 4,871 tumor tissue samples, only 1.8% of solid tumors had RET gene variants, of which ...

Roles of the RET Proto-oncogene in Cancer and Development

RET aberration in diverse cancers: Next-generation sequencing of 4871 patients. Clin Cancer Res. 2017;23 (8):1988-97. 30. Wiesner T, He J, Yelensky ...

RET proto-oncogene and thyroid cancer | Endocrine Pathology

Heterogeneous mutation of the RET proto-oncogene in subpopulations of medullary thyroid carcinoma. Cancer Res 56:2167–2170, 1996. PubMed CAS Google Scholar.

RET Proto-Oncogene - IntechOpen

RET rearrangement in human cancer. In human cancers, RET rearrangement or fusion was first identified in papillary thyroid carcinoma (PTC) at a relatively high ...

Definition of RET gene - NCI Dictionary of Cancer Terms

Mutations (changes) in the RET gene may cause the protein made by this gene to become overactive, which may cause abnormal cells, including cancer cells, to ...

The RET proto‐oncogene: A molecular therapeutic target in thyroid ...

The RET proto-oncogene is responsible for the development of several human ... The RET proto-oncogene in human cancers. Oncogene 2000; 19: 5590–7 ...

RET proto-oncogene - OUCI

Gain-of-function mutations caused by gene rearrangements have been found in papillary thyroid carcinoma, non-small-cell lung carcinoma, and other cancers, while ...

The RET Proto-Oncogene in Multiple Endocrine Neoplasia Type 2 ...

Carcinoid, adrenal cortical, and lipoid tumors may also occur in MEN-1. ... Human Cancer Genetics, the Markey Charitable Trust, the Charles A.

The RET proto-oncogene: A molecular therapeutic target in thyroid ...

Germline point mutations were identified in multiple endocrine neoplasia types 2A and 2B, and familial medullary thyroid carcinoma. More than 10 rearranged ...

The RET proto-oncogene: a potential target for molecular cancer ...

Eng, C. The ret proto-oncogene in the development of human cancer. J ... Jhiang, S.M.. The RET proto-oncogene in human cancers. Oncogene. 2000; 19:5590 ...

(PDF) RET proto-oncogene - ResearchGate

RET fusions helps in diagnosing specific salivary gland carcinomas. Cancer Prevalence RET fusions. Papillary thyroid carcinoma in general popula ...

Impact of RET proto-oncogene analysis on the clinical management ...

... tumor penetrance in this dominantly inherited human cancer syndrome.68. ROUTINE PROCEDURES IN MOLECULAR RET DIAGNOSIS. Investigators working on studies ...

Expression of RET in cancer - Summary - The Human Protein Atlas

The cancer tissue page shows antibody staining of the protein in 20 different cancers ... Full gene name according to HGNC. Ret proto-oncogene. Protein class i.

RET Proto-Oncogene and Its Role in Multiple Endocrine Neoplasia ...

Keywords · Multiple Endocrine Neoplasia Type · Multiple Endocrine Neoplasia · Medullary Thyroid Cancer · Familial Medullary Thyroid Carcinoma · Plasma Calcitonin ...

The RET proto-oncogene in human cancers - EBSCOhost

The clinical relevance of. RET in human diseases was first recognized in papillary thyroid carcinoma (PC), followed by multiple endocrine neoplasia type 2 (MEN ...

ret proto-oncogene - WikiGenes

Thyroid papillary cancers (PTCs) are associated with activating mutations of genes coding for RET or TRK tyrosine kinase receptors, as well as of RAS genes [25] ...