The emerging roles of SUMOylation in the tumor microenvironment ...

Besides, 46 cases of colon cancer were investigated, showing that patients who exhibited high expression of. SUMO1 and SUMOylated P53 were more likely to expe-.

Functions of SUMO cascade in regulating activity of immune related ...

Tumor initiation, progression, and response to therapies depend to a great extent on interactions between malignant cells and the tumor microenvironment ...

The post-translational modification, SUMOylation, and cancer ...

SUMOylation is widely involved in carcinogenesis, DNA damage response, cancer cell proliferation, metastasis and apoptosis.

Role of SUMO activating enzyme in cancer stem cell maintenance ...

Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat. Cell Biol. 12, 468–476 (2010). 50. Huang, H. J. ...

Insights into the post-translational modification and its emerging role ...

Direct targeting tumor microenvironment is the most promising method of tumor therapy, which has great basic and clinical research potential. In ...

The Emerging Role of Deubiquitinases in Radiosensitivity

Radiation therapy is a primary treatment for cancer, but radioresistance remains a significant challenge in improving efficacy and reducing toxicity.

Citations to Activated SUMOylation restricts MHC class I ... - JCI

The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications. Gu Y, Fang Y, Wu X, Xu T, Hu T, Xu Y, Ma P, Wang Q, Shu Y ...

Deciphering the emerging role of SUMO conjugation in the hypoxia ...

The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications. Article. Full-text available. Jul 2023. Yunru Gu · Yuan Fang · Xi ...

Functional Proteomics Study Reveals SUMOylation of TFII-I is ...

SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway. · The emerging roles of SUMOylation in the tumor microenvironment ...

The emerging roles of Oct4 in tumor-initiating cells

... sumoylation, and glycosylation have been identified as ... Cancer stem cell dynamics in tumor progression and metastasis: is the microenvironment to blame?

Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating ...

The cellular inhibition of SAE results in an apparent loss of SUMOylated proteins in the nucleus due to rapid deSUMOylation, catalyzed by SUMO ...

Emerging Roles of SIRT1 in Cancer Drug Resistance - Sage Journals

... sumoylation, and ubiquitination. SIRT1 phosphorylation at ... Although direct roles of SIRT1 in tumor microenvironment–mediated ...

Emerging function and clinical significance of extracellular vesicle ...

Therefore, it is crucial to clarify the molecular mechanism of LC occurrence and development and to identify reliable biomarkers. The tumor microenvironment ( ...

BCR-induced protein dynamics and the emerging role of ... - bioRxiv

Interestingly, our differential expression analysis identified dynamic responses in various proteins previously not linked to early B cell ...

ETS transcription factors and their emerging roles in human cancer

Oncogenes and tumour suppressor genes act as modulators of cell proliferation, while the balance of apoptotic and anti-apoptotic genes controls cell death. All ...

Regulation of mechanotransduction: Emerging roles for septins

Fernando Calvo Tumour Microenvironment Team, Division of Cancer Biology, Institute of Cancer Research, 237 Fulham Road, London, SW2 6JB, UK ...

Citations to this article in year 2023 (11) - JCI

The emerging roles of SUMOylation in the tumor microenvironment and therapeutic implications. Gu Y, Fang Y, Wu X, Xu T, Hu T, Xu Y, Ma P ...

Emerging function of main RNA methylation modifications in the ...

STAT3 is overactivated in immune cells within the tumor microenvironment (TME) [40]. It promotes the production of immunosuppressive factors and inhibits the ...

Emerging roles of plasma gelsolin in tumorigenesis and modulating ...

In this review, we discuss the current knowledge focusing on the roles of gelsolin in inflammation and wound healing, cancers, and tumor microenvironment.

miR-708-5p: a microRNA with emerging roles in cancer | Oncotarget

... roles in regulating the tumor microenvironment (TME). Discovery and ... sumoylation of DICER resulted in decreased pre-miR-708 ...