siRNA Delivery to Cancer Cells by Exosomes

Exosome-Based Carrier for RNA Delivery: Progress and Challenges

RNA molecules can be loaded into exosomes and then delivered to targeted cells or tissues via various biochemical or physical approaches. So far, exosome- ...

A model system for antiviral siRNA therapeutics using exosome ...

EPM technology can deliver both plasmid DNA and siRNA to both simulate viral gene expression and screen potential antiviral siRNA therapeutics.

Exosome‑delivered TRPP2 siRNA inhibits the epithelial ...

Cell migration and invasion are critically involved in the metastasis of laryngeal cancer. Therefore, FaDu cells were treated with exosome/TRPP2 ...

UNCORRECTED PROOF - Glen Research

We have reported the application of RNA nan- otechnology to construct FA-displaying exosomes for efficient cell targeting, siRNA delivery and cancer regres-.

Exosomes as an siRNA delivery vehicle

The researchers show that modified exosomes, containing IL3-Lamp2B, and loaded with Imatinib, are able to specifically target tumor cells in ...

Non-Small-Cell Lung Cancer Regression by siRNA Delivered ...

Keywords: RNA nanotechnology, exosomes, non-small-cell lung cancer, siRNA, EGFR, aptamer. Introduction. Lung cancer is the most common cancer worldwide,.

Exosome-mediated delivery of siRNA in vitro and in vivo. - Abstract

The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is ...

Researchers Use Cholesterol-enriched Exosomes to Improve siRNA ...

RNA interference (RNAi) technology has gradually become a cutting-edge technology for treating diseases such as genetic disorders and cancer ...

Functional siRNA Delivery by Extracellular Vesicle–Liposome ...

More recently, nature's own carriers of RNA, extracellular vesicles (EVs), are increasingly being considered as alternative siRNA delivery ...

iRGD-modified exosomes-delivered BCL6 siRNA inhibit the ...

This study demonstrates a therapeutic potential of exosomes as a promising vehicle for RNAi delivery to treat DLBCL by reducing immunogenicity and ...

Engineering exosomes as refined biological nanoplatforms for drug ...

A number of groups have investigated the use of tumor cell-derived exosomes for delivery of chemotherapeutic agents or other anticancer agents. There are ...

siRNA Loaded-Exosomes | Springer Nature Experiments

We developed a new system that uses intravenous injection of modified exosomes for siRNA delivery into the brain. Here we describe the generation of unmodified ...

Patient-Derived Exosomes as siRNA Carriers in Ovarian Cancer ...

... the therapeutic potential of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The exosomes were extracted from the cultur…

Exosome-mediated Delivery of Hydrophobically Modified siRNA for ...

Exosome-mediated Delivery of Hydrophobic siRNA test ... Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells.

Exosomes functionally deliver siRNAs in vivo to repress tumor growth

In a new study, the VesiCURE team utilized their “dilEVry” platform to load exosomes with tumor-inhibiting siRNAs. When administered ...

Targeted delivery of FAK siRNA by engineered exosomes to reverse ...

FAK siRNA was loaded into these exosomes using electroporation, creating engineered colon cancer cells targeted and FAK siRNA-loaded exosomes ( ...

Non-Small-Cell Lung Cancer Regression by siRNA Delivered ...

In this study, we report the use of RNA nanotechnology to display ligand on exosome that was loaded with small interfering RNA (siRNA) for NSCLC regression in ...

Custom Exosomes Service - Creative Biolabs

As exosomes naturally carry RNA (including shuttle RNA, mainly mRNA and microRNA) between cells, these particles might be useful in genetic cancer therapy to ...

Exosomes for targeted siRNA delivery across biological barriers.

Importantly, a sub-group of these termed exosomes, have recently been shown to contain various RNA species and to mediate their horizontal transfer to ...

Engineered Exosomes for Targeted Transfer of siRNA to HER2 ...

By engineering exosome-producing cells, ligands can be expressed fusing with exosomal surface proteins for targeting cancer cell receptors. In ...