[PDF] A Protein‐Truncating HSD17B13 Variant and Protection from ...

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic ...

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. N. Engl. J. Med. 2018, 378, 1096–1106. [CrossRef]. 11. Tang ...

Therapeutic opportunities for the treatment of NASH with genetically ...

The HSD17B13 protein is located primarily on lipid droplets of hepatocytes. However, the protective genetic variants in HSD17B13 associate with ...

the perfect combination to treat metabolic associated fatty liver disease

A protein-truncating HSD17B13 variant and protection from chronic liver disease. ... PDF · XML. Citation. Cite this Article. RIS BibTex. Meroni M, Longo M ...

HSD17B13: A Potential Therapeutic Target for NAFLD - Frontiers

In the past years, two additional loss-of-function human HSD17B13 variants have been identified, including a protein-truncating variant rs143404524 (p.

Leveraging Human Genetics to Identify Potential New Treatments for ...

2. Abul-Husn, N.S. ∙ Cheng, X. ∙ Li, A.H. ... A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. N. Engl. J ...

Genetics of Metabolic Dysfunction-associated Steatotic Liver Disease

16. Abul-Husn, N.S. ∙ Cheng, X. ∙ Li, A.H. ... A protein-truncating HSD17B13 variant and protection from chronic liver disease. N Engl J ...

Rare variant associations with plasma protein levels in the UK Biobank

... pdf. Reporting summary. Further information on research ... A protein-truncating HSD17B13 variant and protection from chronic liver disease.

Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI ...

jm2c01884_si_001.pdf (5.65 MB) ... ; Dewey, F. E. A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease.

HSD17B13 inhibitor | BI-3231 | opnMe | Boehringer Ingelheim

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. Abul-Husn N. S., Cheng X., Li A. H., Xin Y., Schurmann C., Stevis P., Liu Y ...

Impact of a Loss-of-Function Variant in HSD17B13 on Hepatic ...

A common splice variant in HSD17B13 (rs72613567:TA) was recently found to be associated with a reduced risk of developing chronic liver disease in NAFLD ...

Genetic variants in PNPLA3 and TM6SF2 are risk factors for the ...

A protein-truncating. HSD17B13 Variant and protection from chronic liver disease. N Engl J Med. 2018;378:1096-1106. 22. Yang J, Trépo E, Nahon P, Cao Q ...

Genetics of Nonalcoholic Fatty Liver Disease - Thieme Connect

HSD17B13 gene was found to protect patients with chronic ... A protein-truncating. HSD17B13 variant and protection from chronic liver disease.

17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol ...

Cofactor binding site mutation protein HSD17B13(A)-G47/49A has no RDH ... A protein-truncating HSD17B13 variant and protection from chronic liver disease.

INI-822: TARGETING HSD17B13, A GENETICALLY ... - Inipharm

A Protein-Truncating HSD17B13 Variant and Protection from Chronic Liver Disease. NEJM 2018; 378:1096-1106. 2. Ma Y, et al. Handelman SK. 17-Beta ...

Loss-of-function HSD17B13 variants, non-alcoholic steatohepatitis ...

17β-hydroxysteroid dehydrogenase 13 (HSD17B13) variants were recently reported to have significantly lower odds of non-alcoholic fatty liver ...

Healthy lifestyle? or just the right genetic mutations

new allele variants associated with protection from liver injury ... A protein-truncating hsd17b13 variant and protection from chronic liver.

Genetic variation in HSD17B13 reduces the risk of ... - BORIS

A protein-truncating. HSD17B13 Variant and protection from chronic liver disease. N Engl J Med 2018;378:1096-. 1106. 21. Yang J, Trépo E, Nahon P, Cao Q ...

Is a Hepatic Retinol Dehydrogenase Associated With Histological Fe

Cofactor binding site mutation protein HSD17B13(A)-G47/49A has no RDH ... A protein-truncating HSD17B13 variant and protection from chronic liver disease.

The Protection Conferred by HSD17B13 rs72613567...

HSD17B13 encodes for a liver-specific lipid droplet (LD)–associated protein (11) that seems to be implicated in hepatic-lipid biogenesis and metabolism.

A phase I/II study of ARO-HSD, an RNA interference therapeutic, for ...

This is a PDF file of an article that has undergone enhancements after ... A protein-truncating. HSD17B13 variant and protection from chronic liver disease.