- "USP11 and USP7 Deubiquitinases Regulate SPRTN Auto ...🔍
- Flap endonuclease 1 repairs DNA|protein crosslinks via ...🔍
- Repair of DNA|protein crosslinks in plants🔍
- SPRTN is a mammalian DNA|binding metalloprotease that resolves ...🔍
- The protease SPRTN and SUMOylation coordinate DNA|protein ...🔍
- RAD51–WSS1|dependent genetic pathways are essential for DNA ...🔍
- The DNA‐dependent protease AtWSS1A suppresses persistent ...🔍
- Formation and repair of DNA|protein crosslink damage🔍
A DNA|Dependent Protease Involved in DNA|Protein Crosslink Repair
"USP11 and USP7 Deubiquitinases Regulate SPRTN Auto ...
Additionally, functional DNA-binding proteins such as topoisomerases may become permanently crosslinked to DNA ends by abortive enzymatic processes or targeted ...
Flap endonuclease 1 repairs DNA-protein crosslinks via ... - bioRxiv
... involved in the DNA damage and repair ... The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability ...
Repair of DNA-protein crosslinks in plants - Karlsruhe - KIT - JKIP
Puchta, The protease WSS1A, the endonuclease MUS81, and the phosphodiesterase TDP1 are involved in in- dependent pathways of DNA-protein ...
SPRTN is a mammalian DNA-binding metalloprotease that resolves ...
SPRTN is a protease essential for the repair of cytotoxic DNA-protein cross links and this function is defective in patients afflicted with ...
The protease SPRTN and SUMOylation coordinate DNA-protein ...
The protease SPRTN and SUMOylation coordinate DNA-protein crosslink repair to prevent genome instability. The protease SPRTN and SUMOylation ...
RAD51–WSS1-dependent genetic pathways are essential for DNA ...
Proteases like Wss1 and Tdp1 (tyrosyl-DNA phosphodiesterase-1) are known to be involved in DPCR; however, Tdp1 that selectively removes ...
DPC proteolysis repair has great medical significance since defective DPC protease activity is associated with progeria and cancer predisposition in humans and ...
The DNA‐dependent protease AtWSS1A suppresses persistent ...
The protease WSS1A is an important factor in the repair of DNA-protein crosslinks in plants. Here we show that the loss of WSS1A leads to a ...
Formation and repair of DNA-protein crosslink damage - SciEngine
DNA-protein crosslinks (DPCs)—the covalent linkage of proteins with a DNA strand—are one of the most deleterious and understudied forms of DNA damage, posing as ...
Rapid DNA–protein cross-linking and strand scission by an abasic ...
Apurinic/apyrimidinic (AP) sites are ubiquitous DNA lesions that are highly mutagenic and cytotoxic if not repaired.
Protease Removes DNA-Protein Crosslinks, Restores Replication
Details of this work appeared July 3 in the journal Cell, in an article entitled, “A DNA-Dependent Protease Involved in DNA-Protein Crosslink ...
DNA- and DNA-Protein-Crosslink Repair in Plants - MDPI
Topoisomerases are enzymes crucially needed to ensure the relaxation of the DNA after torsional tension. They function via the active tyrosine ...
The existence of two DPC proteases with distinct modes of action facilitates the degradation of chemically diverse DPCs. Replication-coupled DPC ...
Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...
Cellular, biochemical, and structural studies define a DNA switch triggering its protease activity, a ubiquitin switch controlling SPRTN ...
DNA Damage and DNA Repair: Types and Mechanism
During replication, some DNA polymerases with lower fidelity can be involved ... Finally, DNA ligase then seals any remaining nicks in the ...
But insulin is still secreted into the blood in response to the blood glucose. As a result, glucose accumulates in the blood. The human insulin protein is ...
Is There a Link Between DNA Polymerase Beta and Cancer?
The DNA Repair Interest Group is concerned with all forms of DNA damage and repair. As a major defense against environmental damage to cells DNA ...
Gene ontology. Molecular function. protein binding · ubiquitin protein ligase binding ... "SPOP is essential for DNA-protein cross-link repair in prostate cancer ...
Gram Positive bacteria - Definition, Structure, Characteristics ...
Mechanism of action: Inhibition of nucleic acid synthesis by preventing the transcription of binding DNA-dependent RNA polymerase. Effective against ...