- Induction of Chromosome Instability by Activation of Yes|Associated ...🔍
- Chromosomal Instability in Cancer🔍
- Linking abnormal mitosis to the acquisition of DNA damage🔍
- Chronic myelogenous leukemia stem and progenitor cells ...🔍
- Chromosomal instability upregulates interferon in acute myeloid ...🔍
- HPV16 E6 induces chromosomal instability due to polar ...🔍
- Chromosomal instability and its effect on cell lines🔍
- What is chromosomal instability?🔍
Acquisition of high|level chromosomal instability is associated with ...
Induction of Chromosome Instability by Activation of Yes-Associated ...
Gene expression patterns associated with chromosome instability, called CIN25 and CIN70, were detected in HCCs from patients with shorter survival time or early ...
Chromosomal Instability in Cancer: Causes and Consequences
Structural rearrangements have been associated with chromosomal breakage-fusion-bridge (BFB) cycles that can be initiated by telomeric dysfunction, giving rise ...
Linking abnormal mitosis to the acquisition of DNA damage
Furthermore, chromosome bridges can persist throughout the ensuing cell cycle, and even stretch extensively as cells move far apart (Fig. 3 B), ...
Chronic myelogenous leukemia stem and progenitor cells ...
These studies reveal a previously unrecognized mechanism of chromosomal instability in leukemia progenitors because of continued generation of unstable ...
We observed a nonstatistically significant trend of extremely high chromosome mis-segregation frequency associated with better overall survival (median 13.8 ...
HPV16 E6 induces chromosomal instability due to polar ... - PNAS
Recurrent mitotic errors cause chromosomal instability (CIN), a hallmark of tumors. The E6 and E7 oncoproteins of high-risk human papillomavirus ...
Chromosomal instability and its effect on cell lines - He - 2023
Chromosomal instability (CIN) is one of the primary issues associated with cell lines, which can cause genetic heterogeneity and unstable cell properties ...
What is chromosomal instability? | MD Anderson Cancer Center
Many researchers have shown that chromosome instability is associated with metastasis and resistance to many types of therapy, including ...
Mechanisms of chromosomal instability (CIN) tolerance in ...
CIN can provide survival and adaptation advantages to human cancers. However, too much of a good thing may come at a high cost for tumor cells ...
Role of chromosomal instability in cancer progression
following disruptions at the genetic sequence level. For example, it has been ... (ii) acquired resistance, due to high initial substrate. (tumour cell ...
Sustained expression of miR-26a promotes chromosomal instability ...
Errors in the regulation of DNA synthesis, DNA repair, cell-cycle checkpoint progression, chromosome segregation and completion of cytokinesis ...
Characterizing chromosomal instability-driven cancer evolution and ...
Chromosomal instability (CIN), an increased rate of chromosome segregation errors during mitosis, is a hallmark of cancer cells.
The chromosomal instability pathway in colon cancer. - Europe PMC
The acquisition of genomic instability is a crucial feature in tumor development and there are at least 3 distinct pathways in colorectal cancer ...
Instability is also observed at the whole chromosome level and was first ... population of cells with a high level of genetic variation. This ...
Micronuclear collapse from oxidative damage - Science
Chromosomal instability, a hallmark of aggressive cancers, is characterized by the presence of micronuclei, which are cytosolic rupture-prone ...
Novel Biomarker for Prognosis, Treatment Response - NCI
A high CES, they found, correlated significantly with elevated chromosomal instability of tumors from many cancer types, and with tumor ...
2018 Breast Cancer Highlight - The Link Between Chromosomal ...
Chromosomal instability (CIN) results in an abnormal number or structure of chromosomes within a cell and has been associated with an ...
In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA.
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MethylGPT unlocks DNA secrets for age and disease prediction
It also helps maintain genomic stability through transposable element repression. ... high predictive accuracy. Researchers also evaluated ...