Actin Filaments A Target for Redox Regulation

Conserved Actin Cysteine Residues are Oxidative Stress Sensors ...

and that the actin cytoskeleton is subject to redox regulation [4]. ... Li, Microfilament actin remodeling as a potential target for cancer drug development.

Catastrophic disassembly of actin filaments via Mical ... - OSTI.GOV

Redox Modification of Nuclear Actin by MICAL-2 Regulates SRF Signaling. Lundquist, Mark R.; Storaska, Andrew J.; Liu, Ting-Chun; Cell, Vol. 156, ...

Targeting spectrin redox switches to regulate the ... - De Gruyter

Changes in redox state and treatment with thiol-targeting molecules decrease the deformability of RBCs and affect the structure and stability of ...

Mechanisms of actin disassembly and turnover

In both the demolition and dynamic maintenance pathways, an important control point in network turnover is the attenuation of actin filament ...

IQGAPs as Key Regulators of Actin-cytoskeleton Dynamics - J-Stage

IQGAPs regulate the actin-cytoskeleton alone and with their binding partners, thereby controlling diverse cellular processes, such as cell migration and ...

Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their ...

All isoforms bind preferentially and cooperatively along ADP-subunits in F-actin, affecting the filament helical rotation, and when either alone or when ...

Redox Regulation of Actin by Thioredoxin-1 Is Mediated ... - CiteSeerX

Actin is a highly conserved protein in eukaryotic cells, and has been identified as one of the main redox targets by redox proteomics under oxidative stress ...

Redox Changes of Cultured Endothelial Cells and Actin Dynamics

The rate of incorporation of actin monomers into filaments was fastest at the wound margin, where heightened production of free radicals was ...

A Novel Class of Anticancer Compounds Targets the Actin ...

This specificity of tropomyosin isoform composition provides an opportunity to target distinct actin filament populations both within a given ...

F-actin dismantling through a redo - H1 Connect

He now shows that actin oxidation can synergize with the protein cofilin to modulate actin stability. Given cofilin's established role in growth cone guidance, ...

Actin – a biosensor that determines cell fate in yeasts

This repetitive process allows force generation in the direction of filament growth and is aided by a number of conserved actin regulatory proteins that control ...

DNA damage induces nuclear actin filament assembly by Formin-2 ...

Nuclear actin filaments are also required for nuclear oxidation induced by acute genotoxic stress. Our results reveal a previously unknown role ...

The roles and regulation of the actin cytoskeleton, intermediate ...

c-Abl tyrosine kinase plays a critical role in regulating actin dynamics and migration of airway smooth muscle cells and nonmuscle cells. Recent ...

Identification of Actin as a 15-Deoxy-Δ12,14-prostaglandin J2 Target ...

Type III intermediate filaments in redox interplay: key role of the conserved cysteine residue. ... Actin filaments—A target for redox regulation. Cytoskeleton ...

MsrB1 and MICALs regulate actin assembly and macrophage ...

Actin filaments—A target for redox regulation · Carlos WilsonJ. R. TermanC. González-BillaultGiasuddin Ahmed. Chemistry, Biology. Cytoskeleton. 2016. TLDR. This ...

Calponin Repeats Regulate Actin Filament Stability and Formation ...

Phorbol ester induces actin cytoskeleton rearrangements in cultured vascular smooth muscle cells. Calponin and SM22 α are major components of differentiated ...

Structural and functional mechanisms of actin isoforms - FEBS Press

In cells, treadmilling is regulated by a plethora of regulatory proteins that sequester monomers, cap filament ends, sever and cross-link ...

Reconsidering an active role for G-actin in cytoskeletal regulation

Globular (G)-actin, the actin monomer, assembles into polarized filaments that form networks that can provide structural support, ...

Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time ...

The tropomyosin (Tm) family of actin-binding proteins plays a pivotal role in regulating the function of actin filaments in both muscle and nonmuscle cells.

NOX4 (NADPH Oxidase 4) and Poldip2 (Polymerase δ-Interacting ...

Our results also suggest additional regulatory effects of ROS during cellular adhesion, as we have shown that actin oxidation leads to an increase in vinculin ...