Adenosine receptors and Huntington's disease

Neurobiology of Disease - Fondation Vaincre Alzheimer

Blum, D., Martire, A., Burnouf, S., Sablonnière, B., Krystkowiak, P., Ledent, C., et al., 2012. Adenosine receptors in Huntington's disease.

Caffeine Use in Huntington's Disease: A Single Center Survey

... receptor agonist and phosphodiesterase inhibitor [ 1 ]. Adenosine receptors have been implicated in the pathogenesis of multiple neurodegenerative disorders ...

Adenosine signaling and its downstream target mod(mdg4) modify ...

Dysregulation of adenosine (Ado) homeostasis has been observed in both rodent models and human patients of Huntington's disease (HD). However, ...

Adenosine receptors and brain diseases - CORE

Jenner, Adenosine A2A receptors and Parkinson's disease, Handb. Exp ... Huntington's disease, Neuroscience 81 (1997) 1099–1110. [392] E ...

The Adenosine Receptors - Anticancer Research

This book traces the history of adenosine receptor research from molecular biology to medicinal chemistry, including their implications in disease and ...

The Adenosine A1 Receptor Agonist Adenosine Amine Congener ...

Huntington's disease is a genetic neurodegenerative disorder characterized clinically by both motor and cognitive impairments and striatal ...

Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 ...

Activation of adenosine A2A type receptors renormalized postsynaptic activity to some extent. ... With some limitations, each of these strategies can be used to ...

Catching Up with David Blum | Journal of Caffeine and Adenosine ...

Basically, we demonstrated that the A1 and the A2A receptors were really involved in the control of the striatal degeneration in this rat model ...

Adenosine receptors and neurological disease - AIR Unimi

Adenosine receptors modulate neuronal and synaptic function in a range of ways that may make them relevant to the occurrence, development and treatment of brain ...

Divergent Effects of the Nonselective Adenosine Receptor ...

Divergent Effects of the Nonselective Adenosine Receptor Antagonist Caffeine in Pre-Manifest and Motor-Manifest Huntington's Disease. · Author ...

A COMPARATIVE STUDY OF CANNABINOID, DOPAMINE ...

... receptors at more advanced grades of Huntington's disease (C, D). Scale bar ˆ 1 cm. Table 6. Adenosine A2a receptor levels in Huntington's disease brains—.

Divergent effects of the nonselective adenosine receptor antagonist ...

There is a controversy about potentially positive or negative effects of caffeine consumption on onset and disease progression of ...

Identification of anti-inflammatory targets for Huntington's disease ...

JNK and adenosine 2A (A2A) receptor modulators provide neuroprotection in the brain slice HD assay. (a) Treatment of brain slices with the small molecule JNK ...

a comparative study of cannabinoid, dopamine, adenosine and ...

Finally, advanced grades of Huntington's disease showed an almost total loss of CB1 receptors and the further depletion of D1 receptors in the caudate nucleus, ...

Purine Nucleotides Metabolism and Signaling in Huntington's Disease

P2Y receptors consist of eight subtypes (P2Y1, 2, 4, 6, 11, 12, 13, 14), in which P2Y1,2,4,6 and 11 receptors couple to Gq proteins, activating phospholipase C ...

G protein-coupled receptors in neurodegenerative diseases ... - Nature

NO signaling is associated with various neurodegenerative diseases, including Parkinson's disease, amyotrophic lateral sclerosis, multiple ...

Brain networks in Huntington disease - JCI

A reduction in iSPN GABA release will disinhibit autonomously active GPe neurons, resulting in diminished basal ganglia inhibition of motor ...

Neuronal adenosine A(2A) receptor overexpression is ...

Neuronal adenosine A(2A) receptor overexpression is neuroprotective towards 3-nitropropionic acid-induced striatal toxicity: a rat model of Huntington's disease.

The Brains on Adenosine Receptors - Alomone Labs

However, some areas in the brain also show upregulation of A1 receptors in Alzheimer's Disease34. The involvement of adenosine A1 receptor in AD is further ...

Huntington Disease: Background, Pathophysiology, Etiology

The genetic basis of HD is the expansion of a cysteine-adenosine ... NMDA receptors are depleted in the striata of patients with HD ...

David Blum

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