Chimeric Mice with Humanized Liver

Chimeric Mice With Humanized Livers Demonstrate Human-Specific ...

Chimeric Mice With Humanized Livers Demonstrate Human-Specific Hepatotoxicity Caused by a Therapeutic Antibody Against TRAIL-Receptor 2/Death Receptor 5.

Contribution of Humanized Liver Chimeric Mice to the Study of ...

The reviewed data indicate that chimeric mice with humanized livers have been successfully used for analysing the implications of human hepatic ...

Utility of Chimeric Mice with Humanized Liver for Predicting Human ...

The mice express human drug metabolizing enzymes and transporters in the liver since the mouse hepatocytes are mostly replaced with human ...

Yecuris FRG: Liver-Humanized Mice & Preclinical Research Services

The FRG® KO on NOD was developed to promote the engraftment of both human liver and immune systems.

Chimeric mice with humanized liver as a model for testing ...

Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure. Hiroshi Suemizu,. Corresponding ...

Multi-omics analysis of a fatty liver model using human hepatocyte ...

We developed a fatty liver mouse model using human hepatocyte chimeric mice. As transplanted human hepatocytes do not respond to mouse ...

Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic ...

Here, we study how human hepatocytes with PNPLA3 148I and 148M variants engrafted in the livers of broadly immunodeficient chimeric mice respond ...

Combining Chimeric Mice with Humanized Liver, Mass ...

In this review, drug metabolism and disposition mediated by humanized livers in chimeric mice are summarized in terms of biliary/urinary excretions of phthalate ...

Mice with humanized livers reveal the role of hepatocyte clocks in ...

Liver humanization led to reprogrammed diurnal gene expression and advanced the phase of the liver circadian clock that extended to muscle and ...

Near Completely Humanized Liver in Mice Shows Human-Type ...

These results indicate that human hepatocytes that propagate in mice retain their normal pharmacological responses. We conclude that the chimeric mouse ...

Human liver chimeric mouse model based on diphtheria toxin ...

The researchers provide a novel mouse model of human liver chimeric based on DTR transgenic mice, in which liver injury can be induced by DT injection.

Liver Engineering Laboratory | Department of Applied Research for ...

Liver Engineering Laboratory has been creating a new humanized animal model by modification of NOG mice, especially focusing on development of a liver- ...

Chimeric mouse model of hepatitis B virus infection

Attempts to create mice harboring human chimeric livers led to the establishment of two major models: the urokinase-type plasminogen activator (uPA) transgenic ...

Humanized chimeric mouse models of hepatitis B virus infection

Hepatitis B virus (HBV) infection is associated with an increased risk of hepatic cirrhosis, hepatocellular carcinoma, fulminant hepatitis and end-stage ...

Characterization and Prevention of Hypovitaminosis C in Chimeric

Humanized liver chimeric mice (PXB-mice) are generated by the transplantation of human hepatocytes into mice that have severe combined immunodeficiency and ...

FRG Mice for HBV and HCV Modeling - Yecuris

Human Liver Chimeric Mice Provide a Model for Hepatitis B and C Virus Infection and Treatment · Study Abstract.

A comparison between genetically humanized and chimeric liver ...

Semantic Scholar extracted view of "A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and ...

Human liver chimeric mice provide a model for hepatitis B and ... - JCI

This human liver chimeric mouse model will expand the experimental possibilities for studying HBV and HCV infection, and possibly other human ...

Humanized mice with ectopic artificial liver tissues - PNAS

Elsewhere, humanized mice, based on genetic manipulation or transplantation of human cells, have also been highly enabling (5). Mice with chimeric livers show ...

Mice with 'humanized' livers improve early drug testing, scientist show

The chimeric mice used in the new study varied in the extent to which their livers were composed of human cells. Their overall metabolic ...