• Chromothripsis and chromoplexy in myeloma🔍
• CRISPR and Chromothripsis🔍
• Chromothripsis🔍
• The Complex Structural Variant Chromothripsis Can be Defined on ...🔍
• Full article🔍
• potential origin in gametogenesis and preimplantation cell divisions ...🔍
• Chromothripsis|like chromosomal rearrangements induced by ...🔍
• Chromothripsis in cancer cells🔍

Chromothripsis and chromoplexy in myeloma - YouTube

Gareth Morgan, MD, PhD, FRCP, FRCPath, NYU Langone Medical Center, New York, NY, discusses chromothripsis and chromoplexy, and how these may ...

CRISPR and Chromothripsis: Proceed with Caution

CRISPR-Cas9-induced DNA damage is of particular interest in the realm of cell therapies. When deriving a knockout cell line or genetically ...

Chromothripsis - Science News

All or part of a chromosome may break into pieces, some of which reassemble. Leftover fragments can form DNA circles (colored dots, above) that replicate ...

The Complex Structural Variant Chromothripsis Can be Defined on ...

The Complex Structural Variant Chromothripsis Can be Defined on Targeted Sequencing Panels, Allowing Direct Clinical Translation in Order to ...

Full article: Pathways to chromothripsis - Taylor & Francis Online

In medulloblastomas, chromothripsis has been observed to occur in the context of mutational inactivation of p53 and activation of the canonical Hedgehog (Hh) ...

potential origin in gametogenesis and preimplantation cell divisions ...

Chromothripsis occurrence in human gametes and preimplantation embryos, with regard to the potential causative mechanisms described in literature. Result(s).

Chromothripsis-like chromosomal rearrangements induced by ...

These findings suggested that localized ionizing irradiation within the nucleus may induce chromothripsis-like complex chromosomal alterations via local DNA ...

Chromothripsis in cancer cells: An update - Wiley Online Library

In this review, we will discuss potential mechanisms of chromothripsis initiation in cancer and outline the prevalence of chromothripsis across entities.

Chromothripsis as on-target consequence of CRISPR-Cas9 genome ...

The Pellman Lab found that genome editing can generate abnormal nuclear structures called micronuclei and chromosome bridges.

Comprehensive analysis of chromothripsis in 2658 human cancers ...

... chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive ...

Chromothripsis is correlated with reduced cytotoxic immune ...

Background: Chromothripsis caused massive, clustered genomic rearrangements is prevalent in cancer and is considered a new paradigm for ...

Constitutional chromothripsis of the APC locus as a cause of genetic ...

We propose that constitutional chromothripsis dampening APC expression, possibly modified by additional APC–Axin–GSK3B–β-catenin pathway disruptions, underlies ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

... chromothripsis across 2,658 tumors from 38 cancer types using whole-genome sequencing data. We find that chromothripsis events are pervasive ...

Chromothripsis in High-Risk Myelodysplastic Syndromes: Incidence ...

Chromothripsis is associated with highly complex karyotypes and a very poor prognosis, and has been detected in a wide range of tumor entities, ...

Pan-Cancer analysis of chromothripsis, chromoplexy and kataegis

Overall, kataegis occurs late during tumour evolution, contributing substantially to subclonal diversification. In contrast, chromothripsis and ...

Chromothripsis and progression‑free survival in metastatic ...

In the present study, a correlation between massive DNA fragmentation (chromothripsis) and PFS in mCRC was observed. As opposed to recent ...

Chromothripsis Is a Recurrent Genomic Abnormality in High-Risk ...

The presence of chromothripsis involving chromosome 13 was a novel recurrent change in high-risk MDS patients.

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

Chromothripsis is a newly discovered mutational phenomenon involving massive, clustered genomic rearrangements that occurs in cancer and other ...

Chromothripsis is linked to TP53 alteration, cell cycle impairment ...

Chromothripsis is linked to TP53 alteration, cell cycle impairment, and dismal outcome in acute myeloid leukemia with complex karyotype.

ChromothripsisDB

“Chromothripsis” is a phenomenon characterized in cancer genomes, defined by the occurrence of tens of hundreds of clustered genomic rearrangements, ...