Chromothripsis

Chromothripsis ... Chromothripsis is a mutational process by which up to thousands of clustered chromosomal rearrangements occur in a single event in localised ...

Comprehensive analysis of chromothripsis in 2,658 human cancers ...

Chromothripsis is a mutational phenomenon characterized by massive, clustered genomic rearrangements that occurs in cancer and other ...

Chromothripsis—Explosion in Genetic Science - PMC

Chromothripsis has been defined as complex patterns of alternating genes copy number changes (normal, gain or loss) along the length of a chromosome or ...

Chromothripsis - an overview | ScienceDirect Topics

Chromothripsis is another type of chromosome alteration observed in pancreatic cancer. It is a catastrophic event that occurs during mitosis and possesses the ...

Chromothripsis: Current Biology - Cell Press

Chromothripsis literally means 'chromosome shattering'. Chromosomes that undergo chromothripsis first fragment into many pieces and then get stitched back ...

Chromothripsis and DNA Repair Disorders - PMC

Chromothripsis is a mutational mechanism leading to complex and relatively clustered chromosomal rearrangements, resulting in diverse phenotypic outcomes.

Genetic hallmarks and clinical implications of chromothripsis in ...

Chromothripsis (cth) is a form of genomic instability leading to massive de novo structural chromosome rearrangements in a one-time ...

Chromothripsis, DNA repair and checkpoints defects - ScienceDirect

The high chromothripsis prevalence in tumors developing in patients with germline mutations in major DNA damage checkpoints or DNA repair factors suggests that ...

Chromothripsis: an emerging crossroad from aberrant mitosis to ...

Chromothripsis involves the rapid acquisition of tens to hundreds of structural rearrangements within a short period, leading to complex alterations in one or a ...

Chromothripsis is a common mechanism driving ... - Genome Biology

Local chromosome shattering, termed chromothripsis, is a mechanism proposed to be the cause of clustered chromosomal rearrangements and was ...

Chromothripsis-like patterns are recurring but heterogeneously ...

Chromothripsis is a recently discovered phenomenon of genomic rearrangement, possibly arising during a single genome-shattering event.

A cell‐based model system links chromothripsis with hyperploidy

An in vitro cell‐based model system is developed to enable studies of catastrophic DNA rearrangements, including of chromothripsis events.

Chromothripsis and Focal Copy Number Alterations Determine Poor ...

Chromothripsis and focal copy number alterations determine poor outcome in patients with malignant melanoma, suggesting a role of chromothripsis as a.

On the Complexity of Mechanisms and Consequences of ... - Frontiers

Chromothripsis is characterised by a high frequency of deletions, translocations and inversions (Stephens et al., 2011). These chromosomal aberrations result ...

Chromothripsis Explorer - Park Lab

Chromothripsis Explorer permits to explore and visualize the tumors comprised in the PCAWG cohort, including properties of the tumors (eg purity and ploidy),

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

Chromosomal rearrangements are generally thought to accumulate gradually over many generations. However, DNA sequencing of cancer and ...

Chromothripsis: Methods and Protocols - SpringerLink

This book presents an up-to-date view on methods and experimental approaches developed to identify and explore the chromothripsis phenomenon.

What happens when chromosomes shatter - EMBL-EBI

Chromothripsis, or 'chromosome shattering', is a mutational process in which large stretches of a chromosome undergo massive rearrangements in a single, ...

Pan-cancer analysis of chromothripsis-related gene expression ...

In this study, we found that the transcriptional profile of five tumor types experiencing chromothripsis is associated with an immune evasion phenotype.

Chromothripsis: A New Frontier in Cancer Research

Chromothripsis: A New Frontier in Cancer Research ... Chromothripsis is a process where a single catastrophic event shatters a chromosomal region, ...