Drugging The Undruggable Strategies And Future Directions

Drug resistance mechanisms and treatment strategies mediated by ...

The integration of USP inhibitors with current anti-cancer therapies offers a promising strategy to circumvent drug resistance. Therefore, this ...

Big data and artificial intelligence discover novel drugs targeting ...

Based on our previous research experience in artificial intelligence (AI)-assisted drug discovery, we review the above methods and successful cases to provide a ...

neurodegenerative disease targets with small molecules - SciEngine

Here we discuss recent progress and envision future directions for small molecule drug discovery strategies to tackle ''undruggable” neurodegenerative disease ...

Induced protein degradation for therapeutics: past, present, and future

The concept of induced protein degradation by small molecules has emerged as a promising therapeutic strategy that is particularly effective in targeting ...

Home – Cell Symposia: Chemical biology in drugging the undrugged

This progress has even led to several clinically approved anti-cancer drugs for some challenging targets once considered undruggable. One notable example ...

Developing the next generation of drug delivery technologies

Additional research into the protein corona led by Kai Liu, Senior Scientist, Advanced Drug Delivery, Pharmaceutical Sciences and published in ...

Emerging trends in targeting "undruggable" RAS proteins for cancer ...

Despite their prolificacy, there is a distinct lack of therapies that target these RAS proteins. RAS inhibitors have been investigated in cancer treatment for ...

Unlocking the Undruggable Space | Bayer Global

Many proteins involved in harmful disease processes cannot be targeted by drugs – they are “undruggable”. Targeting them at the level of RNA ...

Drugging the 'undruggable' cancer targets - eScholarship

I put these approaches into two buckets: new strategies inspired by serendipity and expanding our view of drug space. ... Peptide therapeutics: current status and ...

"Rational, Computer-Enabled Peptide Drug Design: Principles ...

... undruggable' intracellular protein ... Rational, Computer-Enabled Peptide Drug Design: Principles, Methods, Applications and Future Directions ...

How Oligonucleotide Drugs Address Undruggable Proteins | WuXi ...

Future directions. As the field of oligonucleotide drugs continues to advance, several key areas are shaping its future trajectory: Emerging therapies: The ...

A drug hunter's new tricks - Sarafan ChEM-H

After building a career on designing drugs that target different proteins, he recently turned his focus to so-called “undruggable” proteins, ...

Combination strategies with PD-1/PD-L1 blockade - Molecular Cancer

RAS-targeted therapies: is the undruggable drugged? Nat Rev ... future directions. Mol Cancer 21, 28 (2022). https://doi.org/10.1186 ...

Cancer Therapeutics Target the Undruggable, Confront Other ...

Biotechnology companies are constructing new discovery platforms and developing completely novel types of drugs. Some of the companies are ...

Small Molecules for neurodegenerative disease - Patsnap Synapse

图片 Different strategies for drugging the “undruggable” targets ... Nonetheless, these results pave the way for future research directions.

What makes something 'undruggable'? - Drug Discovery and ...

The podcast considers the conclusion that approximately 85% of the human proteome remains “undruggable,” meaning that small molecule drugs are ...

Drugging the Undruggable: Therapeutic Potential of Targeting ...

Well-characterized, potent, selective, and bioactive inhibitors are essential tools for functional interrogation of PTPs in disease biology and ...

Lead Generation Strategies | Sept 30 - Oct 3, 2024

The pharmaceutical and biotechnology industry is at an exciting time in small molecule drug discovery, with many more and better ways to generate new ...

Fragment-based drug discovery supports drugging 'undruggable ...

Fragment-based drug discovery (FBDD) has achieved great success in modulating PPIs, with more than ten compounds in clinical trials.

Recent advances in targeting the “undruggable” proteins - OUCI

... development of drug discovery targeting “undruggable” proteins and their applicat ... strategies and future prospective. Med. Res. Rev. 42, 1607–1660 ...