Durotaxis and negative durotaxis

The Forces behind Directed Cell Migration - MDPI

... negative durotaxis' (Figure 2b, orange zone). When modeling this ... Finally, recent results show that single cells are guided toward soft ...

Stopping Cancer Cells' Movement and Changing Their Direction

This 'negative durotaxis' does not coincide with changes in canonical mechanosensitive signaling or actomyosin contractility. Instead, as ...

Ivaska Lab on X: "Another cool review out! @MathildeMthu ...

Another cool review out! @MathildeMthu @aisomursu and @johannaivaska take a deep dive into positive and negative durotaxis in cell migration ...

Durotaxis of Passive Nanoparticles on Elastic Membranes

ing both regular and negative durotaxis. (In the rest of the paper, unless otherwise specified, the term durotaxis describes a passive phenomenon, happening ...

The Focal Adhesion-Localized CdGAP Regulates Matrix Rigidity ...

... durotaxis. Durotaxis plays an important role in normal development and ... negative values, and then averaging them together to give the overall ...

The Forces behind Directed Cell Migration - UB

The new data on negative durotaxis explain such observations and suggest that the interpretation of stiffness patterns may be more complicated ...

Subcellular Force Imbalance in Actin Bundles Induces Nuclear ...

Durotaxis is a phenomenon in which cells migrate toward substrates ... negative cell line by immunofluorescence imaging; and summary of ...

An Elastic-Damaging Cohesive Law for Cell-Substrate Adhesion ...

An Elastic-Damaging Cohesive Law for Cell-Substrate Adhesion with Positive and Negative Durotaxis. 32 Pages Posted: 25 Oct 2023. See all articles by Elena ...

Primer on “Durotaxis” - MECHANO·CONTROL

... Durotaxis”, a cell migration mechanism ... Durotaxis is normally positive, towards stiff regions, but it has also been observed as negative ...

IBEC researchers explain “Durotaxis”, a cell migration mechanism ...

... durotaxis in vivo are likely to emerge. Durotaxis is normally positive, towards stiff regions, but it has also been observed as negative ...

A hybrid computational model for collective cell durotaxis - CORE

3.1 Collective cell durotaxis is more efficient than isolated cell durotaxis ... It is also worth to mention some other works where negative duro- taxis was ...

Rotational constraint contributes to collective cell durotaxis

In addition, collective cell durotaxis is far more efficient than single-cell durotaxis. ... The potential force can be derived as the negative ...

An elastic-damaging cohesive law for cell–substrate adhesion with ...

An elastic-damaging cohesive law for cell–substrate adhesion with positive and negative durotaxis. https://doi.org/10.1016/j.jmps.2024.105569. Journal ...

Elastic interactions compete with persistent cell motility to drive ...

... negative durotaxis in our model. This effect will be explored in future work. In general, our work paves the way for exploring active cell ...

IBEC researchers explain 'Durotaxis', a cell migration mechanism ...

... durotaxis in vivo are likely to emerge. Durotaxis is normally positive, towards stiff regions, but it has also been observed as negative ...

Mechanics of tensegrity cell units incorporating asymmetry and ...

Hence the term negative durotaxis, or mollitaxis, has been coined to indicate the tendency to move toward softer environ- ments. A spontaneous ...

Substrates with Engineered Step Changes in Rigidity Induce ...

during durotaxis. Further, the method employed to generate the step ... negative PDMS (Sylgard 184, Dow-Corning, Midland,. MI) template ...

Durotaxis: the mechanical control of directed cell migration

More precisely, it was shown that DLC1, which is a negative regulator of. RhoA, directly binds to the R8 subdomain within the talin rod domain. Interestingly ...

Mesenchymal stem cell durotaxis depends on substrate stiffness ...

Cells on step gradients migrated at 18.0 ± 0.7 µm/hr, more than 6-fold faster than on other gradient strengths, and it should be noted that negative velocities ...

Directed cell migration towards softer environments. - Research

This 'negative durotaxis' does not coincide with changes in canonical mechanosensitive signalling or actomyosin contractility. Instead, as ...