Eeyarestatin I

Inhibition of ERAD synergizes with FTS to eradicate pancreatic ...

... Eeyarestatin I (EerI). Combined treatment with FTS and EerI significantly upregulated the expression of UPR marker genes and induced ...

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional ... - PLOS

EerI can be divided into a nitrofuran-containing (NFC) and an aromatic domain, which is represented by compounds CBU-002 and 5-NA (5-nitrofuryl-acrolein), ...

Eeyarestatin I | ERAD inhibitor | CAS NO.:412960-54-4 - GlpBio

Eeyarestatin I, a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, is a potent protein translocation inhibitor. It disturbs ...

Eeyarestatin I | CAS#:412960-54-4 | Chemsrc

Chemsrc provides Eeyarestatin I(CAS#:412960-54-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc.

Eeyarestatin 1 from Cayman Chemical | Biocompare.com

An inhibitor of the ERAD pathway, blocking the degradation of misfolded proteins at a dose of 8 µM; associates with the p97-associated deubiquitinating ...

Dissection of the dislocation pathway for type I membrane proteins ...

... eeyarestatin. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Publication information ...

Dual Action of Eeyarestatin 24 on Sec-Dependent Protein Secretion ...

Our results suggest that ES24 not only inhibits the Sec translocon, but also targets bacterial DNA and, in Gram-negative bacteria, the cell membrane.

The ERAD Inhibitor Eeyarestatin I Is a Bifunctional Compound ... - Gale

We recently reported that the ERAD inhibitor Eeyarestatin I (EerI) also disturbs ER homeostasis and has anti-cancer activities resembling that of Bortezomib.

Inhibition of protein translocation at the endoplasmic reticulum ...

Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ESI (eeyarestatin I) is a ...

Eeyarestatin I inhibits Sec61-mediated protein translocation ... - OUCI

Production and trafficking of proteins entering the secretory pathway of eukaryotic cells is coordinated at the endoplasmic reticulum (ER) in a process that ...

Medchem Express 10MG Eeyarestatin I, Quantity - Fisher Scientific

10MG Eeyarestatin I ... Please sign in to purchase this item. Need a web account? Register with us today! This item requires a price update prior to being ordered ...

Eeyarestatin 1 interferes with both retrograde and anterograde ...

Abstract. Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER ...

8DO3: Cryo-EM structure of the human Sec61 complex inhibited by ...

... eeyarestatin. All inhibitors bind to a common lipid-exposed pocket formed by the partially open lateral gate and plug domain of Sec61 ...

Eeyarestatin I Cas 412960 54 4 Calbiochem - Cenmed Enterprises

General description. A cell-permeable oxo-imidazolidinyl-hydroxyurea that preferentially localizes to ER, where it interacts with AAA (ATPase associated ...

Chemical Modulation of Endocytic Sorting Augments Adeno ...

In the current study, we screened a panel of small molecules focused on modulating different cellular degradation pathways and identified eeyarestatin I (EerI) ...

Dissection of the Dislocation Pathway for Type I Membrane Proteins ...

The new inhibitors must therefore interfere with a step that precedes proteasomal degradation. The use of eeyarestatin I thus allows the definition of a new ...

Eeyarestatin Compounds Selectively Enhance Sec61-Mediated Ca

Eeyarestatin 1 (ES1) inhibits p97-dependent protein degradation, Sec61-dependent protein translocation into the endoplasmic reticulum (ER), ...

Eeyarestatin I 1PC X 25MG | SIG324521-25MG | SIGMA-ALDRICH

Eeyarestatin I 1PC X 25MG. Code: SIG324521-25MG D2-0. ADD. Your Price. €300.00 EACH. €369.00 inc. VAT. REQUEST. REQUEST A QUOTE ...

Eeyarestatin 1 Interferes with Both Retrograde and Anterograde ...

The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein ...

EP 3909578 A1 20211117 - ANTIVIRAL COMPOSITION ...

Title (de). ANTIVIRALE ZUBEREITUNG ENTHALTEND EEYARESTATIN I. Title (fr). COMPOSITION ANTIVIRALE À BASE D'EEYARESTATIN I. Publication.