Effect of tumor necrosis factor|alpha antagonism in asthma

Role of TNFα in pulmonary pathophysiology - Respiratory Research

Tumor necrosis factor alpha (TNFα) is the most widely studied pleiotropic cytokine of the TNF superfamily. In pathophysiological conditions ...

Elevation of serum soluble tumour necrosis factor (TNF) receptor ...

effect of these inhibitors exist in several inflammatory diseases. In the ... and IL-1 receptor antagonist (IL-1Ra) in patients with bronchial asthma and normal ...

Role of tumor necrosis factor–α and its receptors in diesel exhaust ...

The clinical use of TNF-α inhibitors in the treatment of obstructive lung diseases such as asthma and chronic obstructive pulmonary disease is ...

TNF inhibitor - Wikipedia

A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response ...

Tumor Necrosis Factor Antagonist Responsiveness in a United ...

A minority of patients (5.4%-19.4%) prescribed TNF antagonists met trial eligibility criteria and predominantly had high disease activity (78.5%-100%). For ...

ANTI-TNF·: BENEFICIAL OR HAMFUL FOR THE LUNG?

Erin EM, Leaker BR, Nicholson GC, Tan AJ et al. The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma.Am J Respir Crit ...

Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis ...

Tumor necrosis factor (TNF) antagonists are popular therapies for inflammatory diseases. These agents enhance the numbers and function of regulatory T cells ...

Tumor Necrosis Factor Alpha Blockade and Multiple Sclerosis

Targeting of TNFR2 may be used to treat cancer and autoimmune diseases due to its protective and anti-inflammatory effects on cardiomyocytes, ...

Cytokine-directed therapies in asthma - J-Stage

Inhibition of tumor necrosis factor (TNF)-α may be useful in severe asthma. Many chemokines are involved in the inflammatory response of asthma and several ...

Anti Tumor Necrosis Factor Alpha And Asthma | PPT - SlideShare

Treatment with the TNF-α antagonist etanercept was associated with improvements in asthma-related quality of life scores, lung function, and exacerbations.

Tumor necrosis factor-α in severe corticosteroid-refractory asthma

Tumor necrosis factor (TNF)-α is a proinflammatory cytokine. Blocking TNF-α has been demonstrated to be effective in various diseases, including both ...

Antagonism of cytokine-induced eosinophil accumulation in asthma

TNF-α has pro-inflammatory effects on eosinophils, neutrophils, T cells, epithelial cells and endothelial cells and may play a key role in amplifying airway ...

Association between Tumor Necrosis Factor-α rs1800629 ... - PLOS

Subgroup analyses found that the TNF-α rs1800629 polymorphism was significantly associated with asthma risk in West Asians and South Asians (OR = 2.47, 95% CI = ...

308 G/A on their serum production and severity of Asthma disease

antagonist coating on neural electrodes ... protective role in asthma pathogenesis17. In same ... (2005): Associations of Tumor Necrosis. Factor G-308A with ...

Targeting the interleukin pathway in the treatment of asthma

... asthma exacerbations during response to an anti-IL-4 receptor alpha antagonist ... Evidence of a role of tumor necrosis factor alpha in refractory asthma. N ...

Medline ® Abstracts for References 30-32 of 'Investigational agents ...

RATIONALE The treatment effect of golimumab, a human monoclonal antibody against tumor necrosis factor (TNF)-alpha, in severe persistent asthma is unknown.

Protective effect of cysteinyl leukotriene receptor antagonist ...

TNF-a: Tumor necrosis factor-alpha; TGF-b1 ... A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma ... Recombinant human tumor necrosis factor- ...

Blocking tumor necrosis factor paved the way for targeted...

The tumor necrosis effect of TNF is actually an indirect action, that is, TNF induces inflammation leading to hemorrhagic necrosis of tumor ...

DP2 antagonism reduces airway smooth muscle mass in asthma by ...

Computational simulations of an asthmatic airway predicted that this decrease in airway smooth muscle mass was due to both amelioration of ...

Macrophage dysfunction in the pathogenesis and treatment of asthma

Corticosteroids are one of the most commonly prescribed medications for the treatment of asthma. Corticosteroids exert anti-inflammatory effects and may target ...