Efficacy and safety of trabectedin or dacarbazine for the treatment of ...

TRAbectedin in adVanced rEtroperitoneal well differentiated ...

... treatment, PFS and safety profile. ... 21. Demetri, G.D. ∙ von Mehren, M. ∙ Jones, R.L. ... Efficacy and safety of trabectedin or dacarbazine ...

Overall survival and histology-specific subgroup analyses from a

KEYWORDS: dacarbazine, trabectedin, leiomyosarcoma, liposarcoma, soft tissue sarcoma. INTRODUCTION. Effective treatment for patients with ...

Real-World Experience of Efficacy and Safety of Trabectedin in ...

The rate of disease control was 46% at the end of treatment. Myxoid liposarcoma (n = 11) was the histology subtype that benefited most from this ...

Efficacy and tolerability of trabectedin in elderly patients with sarcoma

Treatment exposure was longer in patients treated with trabectedin versus dacarbazine (median four versus two cycles, respectively), with a ...

Safety and Efficacy in the Treatment of Advanced Sarcoma

Trabectedin (ecteinascidin 743, ET-743, Yondelis) is a newly developed alkylating agent that has shown significant broad spectrum potential as a single agent ...

Trabectedin for soft tissue sarcoma - Australian Prescriber

The median overall survival was 13.7 months with trabectedin and 13.1 months with dacarbazine. Trabectedin is a very toxic drug. Nearly all ...

The Role of Trabectedin in Soft Tissue Sarcoma - Frontiers

The safety profile for elderly trabectedin-treated patients was ... Efficacy and Safety of Trabectedin or Dacarbazine for. Metastatic ...

Trabectedin (Yondelis) - Medical Clinical Policy Bulletins - Aetna

Yondelis is indicated for the treatment of patients with unresectable or metastatic liposarcoma or leiomyosarcoma who received a prior anthracycline-containing ...

Trabectedin as Second-Line Treatment in Advanced Soft Tissue ...

This review examines data on the safety of trabectedin in the management of patients with aSTS as reported in clinical trials and real-world studies. Evidence ...

Eribulin versus dacarbazine in patients with leiomyosarcoma - Nature

Efficacy of eribulin in patients with leiomyosarcoma was comparable to that of dacarbazine. Both agents had manageable safety profiles.

Trabectedin for Soft Tissue Sarcoma: Current Status and Future ...

Efficacy and safety of trabectedin or dacarbazine for metastatic ... Efficacy and safety of trabectedin as an early treatment for ...

Efficacy and safety of trabectedin in metastatic uterine leiomyosarcoma

Overall, 232 of 577 patients had uLMS and were treated with trabectedin 1.5 mg/m2 by 24-hour intravenous infusion. (n = 144) or dacarbazine 1 g/ ...

Update on the role of trabectedin in the treatment of intractable soft

Second-line therapies include cytotoxic drugs, such as ifosfamide, dacarbazine, gemcitabine, and taxanes, but data from randomized trials on ...

In Brief: Two Drugs for Soft-Tissue Sarcoma (online only)

The FDA recently approved the minor groove DNA intercalator trabectedin (Yondelis – Janssen) for treatment of unresectable or metastatic ...

Trabectedin Boosts PFS Over Dacarbazine in Uterine ...

Hensley ML, Patel SR, Mehren MV, et al. Efficacy and safety of trabectedin or dacarbazine for the treatment of patients with uterine ...

TRAbectedin in adVanced rEtroperitoneal well differentiated

dergoing surgery after treatment, PFS and safety ... Efficacy and safety of · trabectedin or dacarbazine for metastatic liposarcoma or leiomyo-.

Trabectedin (Yondelis) for Liposarcoma or Leiomyoscarcoma

controlled study (SAR-3007) that compared the efficacy and safety of trabectedin with dacarbazine. Patients received trabectedin at a dose ...

207953Orig1s000 - accessdata.fda.gov

(Trabectedin) or Dacarbazine for the Treatment of Advanced Liposarcoma or ... severity, and safety in the trabectedin group and dacarbazine group.

Yondelis (Trabectedin) Approved for the Treatment of Unresectable ...

The FDA approval of trabectedin was based on a randomized, open-label, active-controlled study (Study 1) that demonstrated its clinical efficacy and safety in ...

Safety and Efficacy of the Combination Lurbinectedin plus ...

While cytotoxic chemotherapy is the standard first-line treatment for patients with metastatic soft-tissue sarcoma (STS), clinical outcomes ...