Endoplasmic Reticulum Stress As a Therapeutic Target in ...

Endoplasmic reticulum stress‑induced cell death as a potential ...

IRE1 is the main mediator of the UPR (134). When cancer cells trigger ER stress in an unfavorable environment, the IRE1 signal can be an ...

Endoplasmic Reticulum as a Therapeutic Target in Cancer: Is there...

Steady stimulation of ER stress can switch autophagy to apoptosis. The connection between ER stress and cancer, in association with UPR, has been explained. The ...

a potential therapeutic target for inflammatory disorders - UQ eSpace

It is now widely accepted that both endoplasmic reticulum (ER) stress and inflammasomes play critical roles in activating inflammatory signalling cascades.

Endoplasmic reticulum stress and the development of endothelial ...

In this regard, the endoplasmic reticulum (ER) has recently emerged as an important regulator of metabolic processes. Dysfunction within the ER, broadly termed ...

Endoplasmic Reticulum Stress and Cancer

These cells must overcome perturbations in ER function and ER stress to survive. If unresolved ER stress can lead to apoptosis. The imbalance ...

Endoplasmic reticulum stress in spinal and bulbar muscular atrophy

Our results therefore indicate that the endoplasmic reticulum stress pathway could potentially be a therapeutic target for spinal and bulbar muscular atrophy.

The complex interplay between endoplasmic reticulum stress and ...

The complex interplay between endoplasmic reticulum stress and the NLRP3 inflammasome: a potential therapeutic target for inflammatory ...

Endoplasmic Reticulum Stress Signaling in Cancer Cells

Together, these conditions can promote the buildup of misfolded proteins in the ER to cause ER stress, which then activates the unfolded protein ...

The Role of Endoplasmic Reticulum Stress and Its Regulation in the ...

The unfolded protein response (UPR) is a cellular mechanism activated by endoplasmic reticulum (ER) stress, which ranges from inhibition of protein ...

Endoplasmic Reticulum as a Therapeutic Target in Cancer

Steady stimulation of ER stress can switch autophagy to apoptosis. The connection between ER stress and cancer, in association with UPR, has ...

Novel targets for endoplasmic reticulum stress-induced apoptosis in ...

A better understanding of apoptotic signaling in B-chronic lymphocytic leukemia (B-CLL) cells may help to define new therapeutic strategies.

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease

ER stress–targeted therapies have begun to emerge using approaches that range from global enhancement of chaperone function to selective ...

ENDOPLASMIC RETICULUM STRESS IN SEPSIS

We also discuss the potential implication of ER stress as a novel therapeutic target and prognostic marker in patients with sepsis. Keywords. ER stress; UPR; ...

Unfolded protein response activated by endoplasmic reticulum ...

In particular, unfolded protein response is activated by endoplasmic reticulum stress and plays an important role in the modulation of complex pancreatic tumor ...

Improvement of chemotherapeutic drug efficacy by endoplasmic ...

... endoplasmic reticulum (ER) stress, has been used to improve anticancer drug efficacy, but the underlying mechanism remains obscure. In this study, we show ...

Endoplasmic reticulum stress protects human thyroid carcinoma cell ...

Endoplasmic reticulum stress protects human thyroid carcinoma cell lines against ionizing radiation-induced apoptosis. Authors:.

Combining the Endoplasmic Reticulum Stress–Inducing Agents ...

Endoplasmic reticulum stress has emerged as a potential therapeutic target, and two relatively new drugs, fenretinide and bortezomib (Velcade), each acting via ...

Endoplasmic reticulum stress and therapeutic... - Meditact

As ER stress ensues, the unfolded protein response (UPR), comprising three signaling pathways-inositol-requiring enzyme 1, protein kinase R-like endoplasmic ...

Pathogenic proteotoxicity of cryptic splicing is alleviated by ... - Science

Three different ER-UPR pathways are activated by three different receptors: PERK, IRE1, and ATF6 (33). The source of ER stress determines which ...

Sigma-1 receptor - Wikipedia

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling ...