Engineered exosomes delivering specific tumor|suppressive RNAi ...

The extracellular RNA and drug resistance in cancer: a narrative ...

In one report, higher level of miR-21 in exosomes, which were secreted from cisplatin-resistant oral squamous cell carcinoma, was proved to downregulate the ...

iRGD-modified exosomes-delivered BCL6 siRNA inhibit the ...

This study demonstrates a therapeutic potential of exosomes as a promising vehicle for RNAi delivery to treat DLBCL by reducing immunogenicity and ...

Engineered exosomes shut down pancreatic tumor growth in mice

The study demonstrated that iExosomes were able to deliver KRAS-specific targeting genetic material called siRNA and shRNA, and were more ...

Generation and testing of clinical-grade exosomes for ... - JCI Insight

Previous studies showed that oncogenic Kras-controlled macropinocytosis in pancreas cancer cells increases exosomes uptake (17, 18) and enhances ...

Engineered Exosomes for Targeted Transfer of siRNA to HER2 ...

By engineering exosome-producing cells, ligands can be expressed fusing with exosomal surface proteins for targeting cancer cell receptors. In ...

siRNA Delivery to Cancer Cells by Exosomes | Protocol Preview

... exosome isolation protocol with high yield and purity for siRNA delivery. We also encapsulated fluorescently labelled non-specific siRNA into ...

Delivery of engineered primary tumor-derived exosomes to ...

Tumor-bearing mice treated with the siRNA-delivering exosomes and hepatectomy showed ideal overall survival. These results provide a ...

Cell culture - Wikipedia

Tissue culture commonly refers to the culture of animal cells and tissues, with the more specific term plant tissue culture being used for plants. The ...

In vivo self-assembled, exosome delivered small RNAs as a new ...

RNAi therapy has undergone two stages of development, direct injection of synthetic siRNAs and delivery with artificial vehicles or ...