Epigenetic foundations of pluripotent stem cells that recapitulate in ...

Stem Cells and Epigenetic Reprogramming - IntechOpen

Understanding the fundamentals of this reprogramming process by comparing it to the pluripotent state of ESCs will give us many tools to be able ...

Wolf Reik - Babraham Institute

These three lineages are the foundations of all organs in the adult body and we are interested in the transcriptional and epigenetic events that underlie their ...

Key Role of Epigenetic Information in Stem Cell Function unveiled

Researchers revealed the importance of the transmission of epigenetic information through cell division for embryonic stem cells functionality.

Induced Tissue-Specific Stem Cells and Epigenetic Memory in ...

Induced pluripotent stem (iPS) cells have significant implications for overcoming most of the ethical issues associated with embryonic stem ...

Human Pluripotent Stem Cell–Derived TSC2-Haploinsufficient ...

Cells Recapitulate Features of ... Foundation (168; ref. 15) in 2009. H9 ESCs were obtained from. WiCell Institute ... subjected to epigenetic reprogramming.

Epigenetic mechanisms that enforce pluripotency in embryonic stem ...

Public Abstract: Embryonic stem (ES) cells have the unique ability to self-renew while maintaining a pluripotent state. They can readily be differentiated into ...

発表論文 | 山田研究室東京大学医科学研究所

Yagi M, Yamanaka S, Yamada Y. Epigenetic foundations of pluripotent stem cells that recapitulate in vivo pluripotency. Lab Invest. 2017 Oct;97(10):1133-1141 ...

Pluripotency and Differentiation in Normal and Cancer Stem Cells

To realize the therapeutic potential of iPSC, advances in how to control and direct epigenetic changes are required so that differentiated cell types can be ...

Fixing the Problem With Induced Pluripotent Stem Cells - The Scientist

A new strategy prevents reprogramming-induced epigenetic aberrations in human induced pluripotent stem cells.

Induced pluripotent stem cells reprogramming: Epigenetics and ...

Therefore, further investigations of epigenetic modifications associated with iPSC reprogramming are required in an attempt to improve their self-renew capacity ...

New reprogramming factor cocktail produces therapy-grade induced ...

... epigenetic abnormalities that lower the cells ... – Induced pluripotent stem cells (iPSCs)—adult cells reprogrammed back to an embryonic ...