Expression and clinical significance of the m6A reader YTHDF2 in ...

Bioinformatics analysis of the correlation between m6A RNA ...

Results: Genomic alterations in the m6A regulators were linked to a poor BC prognosis. HNRNPA2B1, HNRNPC, IGF2BP2, RBM15, YTHDF1, and YTHDF2 ...

Ythdf2 | Sigma-Aldrich

YTH domain family 2 (YTHDF2) is an N6-methyladenosine (m6A) binding protein promoting mRNA degradation in various biological processes.

m6A RNA methylation: from mechanisms to therapeutic potential

The mammalian YTHDF family of proteins, consisting of YTHDF1, YTHDF2, and YTHDF3, are cytosolic m6A readers that regulate m6A degradation and ...

The functional roles, cross-talk and clinical implications of m6A ...

demonstrated that YTHDF2 expression was negatively associated with ... The m6A modification site of circRNA could be recognized by “reader”. YTHDF2.

The mRNA m6A reader YTHDF2 suppresses proinflammatory ...

Thus, our study positions YTHDF2 as a repressor of inflammatory pathways in HSCs and highlights the significance of m6A in long-term HSC maintenance.

The RNA m6A reader YTHDF2 maintains oncogene ... - Lab

The RNA m6A reader YTHDF2 maintains oncogene expression ... To further understand the clinical significance and pan-cancer dependency on YTHDF2 ...

Crosstalk between m6A and coding/non-coding RNA in cancer and ...

Growing studies support that YTHDF2 not only plays a pro-tumorigenic role but also serves as a suppressor for various cancers. A higher expression level of ...

YTHDF2 - YTH domain-containing family protein 2 - UniProt

The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation ( ...

The m 6 A reader YTHDF2 is a negative regulator for dendrite ...

However, the underlying mechanisms remain elusive. Here we find that the m6A reader YTHDF2 is highly expressed in the mouse RGCs. Conditional ...

m6A reader Ythdf3 protects hematopoietic stem cell integrity under ...

(A) Expression of YTHDF1, YTHDF2, and YTHDF3 mRNA in CD34+ cells from healthy individuals. (B) Diagram showing the strategy for generating a mouse with the ...

Ythdf2 | Sigma-Aldrich

This study was aimed to explore the mRNA expression of m6A ... m6A Reader YTHDF2 Regulates LPS-Induced Inflammatory Response. ... The function of the m6 A reader ...

The Landscape and Prognostic Value of m6A Methylation-related ...

YTHDF3, YTHDF2, and YTHDF1 in the 'reader' ... (A). Heatmap showing gene expression RNA-seq of the four genes screened above and clinical ...

The m6A reader YTHDF2 is a negative regulator for - ProQuest

Thus, elucidation of mechanisms governing RGC dendrite arbor maintenance bears clinical significance. N6-methyladenosine (m6A) is the most widely ...

The RNA m6A Reader YTHDF2 Maintains Oncogene Expression ...

... YTHDF2-MYC-IGFBP3 axis as a specific and novel therapeutic target in glioblastoma. SIGNIFICANCE: Epitranscriptomics promotes cellular heterogeneity in ...

N6-Methyladenosine - Wikipedia

These binding proteins are named m6A readers. The YT521-B homology (YTH) domain family of proteins (YTHDF1, YTHDF2, YTHDF3 and YTHDC1) have been characterized ...

Decoding the interplay between m6A modification and stress ...

The mechanism is that YTHDF2 can regulate SG stability through the interaction with G3BP1 in m6A-modified RNA-dependent manner. Our results ...

YTHDF2 protein expression summary - The Human Protein Atlas

YTH N6-methyladenosine RNA binding protein 2 · YTHDF2 (CAHL, HGRG8, NY-REN-2).

Supplementary Data from The RNA m6A Reader YTHDF2 Maintains ...

Supplementary Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.

The biological function of m6A reader YTHDF2 and its role in human ...

Abstract N6-methyladenosine (m6A) modification is a dynamic and reversible post-transcriptional modification and the most prevalent internal RNA modification in ...

Data from The RNA m6A Reader YTHDF2 Maintains Oncogene ...

Data from The RNA m6A Reader YTHDF2 Maintains Oncogene Expression and Is a Targetable Dependency in Glioblastoma Stem Cells.