- Xbp1|Independent Ire1 Signaling Is Required for Photoreceptor ...🔍
- Structure and Molecular Mechanism of ER Stress Signaling by the ...🔍
- IRE1 Signaling and ER Stress Levels Increase With Age in Retina🔍
- Dual and opposing roles of the unfolded protein response ...🔍
- IRE1|XBP1 Cell Stress Assay #U0921G🔍
- BAX and BAK expression triggers multiple IRE1 signaling outputs ...🔍
- Impairment of both IRE1 expression and XBP1 activation is a ...🔍
- Marburg virus regulates the IRE1/XBP1|dependent unfolded protein ...🔍
IRE1/XBP1 and endoplasmic reticulum signaling
Xbp1-Independent Ire1 Signaling Is Required for Photoreceptor ...
Introduction. The endoplasmic reticulum (ER) is the cell organelle where secretory and membrane proteins are synthesized and folded. When the ...
Structure and Molecular Mechanism of ER Stress Signaling by the ...
... pathways with a similar outcome to IRE1-XBP1 transcriptional activation (Yoshida et al., 2001). However, ATF6 contrasts significantly from both IRE1 and ...
IRE1 Signaling and ER Stress Levels Increase With Age in Retina
XBP1 encodes a transcription factor whose gene targets include ER protein-folding chaperones. Here, we report the levels of ER stress monitored in real-time in ...
Dual and opposing roles of the unfolded protein response ... - PNAS
In response to upstream signals, XBP1 mRNA undergoes an unconventional splicing by the ER transmembrane endoribonuclease IRE1 which ultimately generates the ...
IRE1-XBP1 Cell Stress Assay #U0921G - Montana Molecular
... (ER-mediated) stress or undergoes the unfolded protein response (UPR). ... Molecular mechanisms involved in alcohol craving, IRF3, and endoplasmic reticulum stress ...
ERN1 - endoplasmic reticulum to nucleus signaling 1 - WikiGenes
A second UPR pathway mediated by activation of IRE1 and its downstream target XBP1 is also required for hypoxia tolerance in vitro and for tumor growth [3].
BAX and BAK expression triggers multiple IRE1 signaling outputs ...
Here we provide preliminary evidence indicating that BAX and BAK deficiency increases the in 10 folds the threshold of ER stress to induce XBP1 mRNA splicing.
Impairment of both IRE1 expression and XBP1 activation is a ...
Importantly, other ER stress response pathways were similar in both subtypes, as measured by activating transcription factor 6 (ATF6) and protein kinase R-like ...
Marburg virus regulates the IRE1/XBP1-dependent unfolded protein ...
Prolonged ER stress can trigger terminal UPR, resulting in apoptosis [Citation4,Citation5]. The UPR encompasses three signalling pathways [Citation3,Citation6] ...
XBP1 signalling is essential for alleviating mutant protein ... - PLOS
IRE1 is the most conserved UPR pathway, with XBP1 as its main effector. Interestingly, in our study we show that chondrocyte response to ER ...
Palmitate-Induced IRE1–XBP1–ZEB Signaling Represses ...
We propose that palmitate activates the IRE1–XBP1 branch of the endoplasmic reticulum (ER) stress pathway to upregulate the ZEB transcription factor, leading to ...
A guide to assessing endoplasmic reticulum homeostasis and stress ...
... endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering. ... activation of XBP1s and/or ATF6 reveals three functionally diverse ER ...
A New Link in the Chain: Unspliced XBP1 in Wnt Signaling and ...
... XBP1s. XBP1s serves as an effector of ER stress sensing provided by IRE1-α, promoting the expression of a set of UPR target genes including ER ...
Genome-wide mRNA profiling identifies X-box-binding protein 1 ...
Endoplasmic reticulum to nucleus signaling 1 (a.k.a. IRE1). FOXJ2 ... endoplasmic reticulum stress response element regulated by XBP1. J ...
Obesity impacts placental function through activation of p-IRE1a ...
... ER stress signaling by the unfolded protein response signal activator IRE1. ... endoplasmic reticulum stress, IRE1α, XBP1S, chaperones. Citation ...
Stress sensor Ire1 deploys a divergent transcriptional program in ...
In mammals, the UPR regulates gene expression by signaling through the ER stress sensors IRE1, ATF6, and PKR-like endoplasmic reticulum kinase ( ...
homeostasis, cell death and evolution in virus infections | FEMS ...
Ire1 signalling has distinct downstream effects, most prominently Xbp1s, which activates a group of UPRER target genes (Acosta-Alvear et al.
In response to endoplasmic reticulum (ER) stress, protein kinase RNA (PKR)-like ER kinase (PERK), similar to inositol-requiring protein-1 (IRE1) ...
Endoplasmic Reticulum Stress Signaling in Cancer Cells
... endoplasmic reticulum kinase (PERK) ... 108. Zhao, N. ∙ Cao, J. ∙ Xu, L. ... Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway ...
Flavivirus Infection Activates the XBP1 Pathway of the Unfolded ...
ABSTRACTThe unfolded protein response (UPR) is a coordinated change in gene expression triggered by perturbations in functions of the endoplasmic reticulum ...