In|vitro models of disc degeneration – A review of methods ...

Molecular therapy of the intervertebral disc - Orthobullets

All of these molecules have some in vitro data, but few have been tested in vivo with an animal model of disc degeneration (Table 4). Each of ...

Intervertebral Disc Degeneration - The American Journal of Pathology

Mouse models of IVD degeneration were used to investigate the role of the mechanical stress in this process. The application of mechanical overload (1.3 MPa) ...

Leptin and the intervertebral disc: a biochemical link exists between ...

... disc degeneration and low back pain—an in vitro study in a bovine model ... analysis for the Global Burden of Disease Study 2010. Lancet ...

Small molecule-based treatment approaches for intervertebral disc ...

CLBP is a multifactorial and complex clinical presentation, and symptomatic intervertebral disc (IVD) degeneration (IDD) is considered as the major cause of ...

Orthobiologic Management Options for Degenerative Disc Disease

This review comprehensively outlines the pathophysiology of DDD, highlighting the inadequacies of existing pharmacological therapies and detailing the ...

MRI findings of disc degeneration are more prevalent in adults with ...

MATERIALS AND METHODS: We performed a meta-analysis of studies reporting the prevalence of degenerative lumbar spine MR imaging findings in asymptomatic and ...

Intervertebral disc tissue engineering: A brief review.

Advances in manufacturing techniques, material processing and development, surface functionalization, drug delivery systems and cell incorporation furthered ...

Epoxyeicosanoids prevent intervertebral disc degeneration in vitro ...

We used a disc puncture procedure to model IVD degeneration in rats, which is the most commonly used method. Moreover, the disc puncture ...

Gene Therapy Approach for Intervertebral Disc Degeneration

70 reported prolonged ef- fectiveness of the DNA vector-based RNAi technique in vitro. ... intervertebral disc degeneration in an in vivo rabbit ...

Systematic Literature Review of Imaging Features of Spinal ...

CONCLUSIONS: Imaging findings of spine degeneration are present in high proportions of asymptomatic individuals, increasing with age. Many ...

Novel therapeutic strategies for degenerative disc disease

Experiments in a mouse IVD model revealed a linear correlation of IVD cell apoptosis as static compression loads on the endplates were increased ...

Papain-induced in vitro disc degeneration model for the study of ...

Raj, Intervertebral disc: anatomy-physiology-pathophysiology-treatment, Pain Pract, № 8, с. · Leone, Amidic alginate hydrogel for nucleus pulposus replacement, J ...

Tissue engineering approaches to degenerative disc disease

The results of the reviewed animal models may have only limited value for a human application. ... A systematic review of their method- ologies.

Animal Models of Intervertebral Disc Degeneration - Lippincott

In vitro cell and organ culture models are used commonly and are useful for identifying short-term events. These are powerful techniques that allow hypothesis ...

In vitro and in vivo evaluation of discogenic cells, an investigational ...

Disc degeneration (DD) is a significant driver of low back pain and few treatments exist to treat the pain and disability associated with the ...

MUC1 and CREB3 are hub ferroptosis suppressors for nucleus ...

Researchers have recognized that reduced intervertebral disc cell numbers or cell death and extracellular matrix (ECM) degradation are pivotal ...

Endplate role in the degenerative disc disease: A brief review

... methods for intervertebral disc regeneration ... vitro cell models, concerned with processes of intervertebral disc degeneration.

The cellular pathobiology of the degenerate intervertebral disc and ...

Molecular pathology has shown IVD degeneration, a major cause of low back pain, to be a complex, active disorder in which disturbed cytokine ...

In Vivo Mouse Intervertebral Disc Degeneration Model Based on a ...

Although human intervertebral disc degeneration can lead to several spinal diseases, its pathogenesis remains unclear. This study aimed to create a new ...

Biomechanics of intervertebral disk degeneration. - Europe PMC

In this review, we will address on the degenerative changes in the material properties of nucleus pulposus and anulus fibrosus followed by the changes in ...