- Germline mutations causing familial lung cancer🔍
- Genomic Evolution in a Patient With Lung Adenocarcinoma With a ...🔍
- Lung cancer — Knowledge Hub🔍
- What Women Need to Know About Lung Cancer🔍
- EGFR|Mutant Non–Small Cell Lung Cancer in the Era of Precision ...🔍
- Lung Cancer Symptoms in People Who've Never Smoked🔍
- Identification of Genetic Mutations in Human Lung Cancer by ...🔍
- Beyond tobacco🔍
Inherited lung cancer syndromes targeting never smokers
Germline mutations causing familial lung cancer - Nature
Smoking is an environmental predisposing factor; exposure to tobacco smoke causes genetic alterations and is strongly associated with lung ...
Genomic Evolution in a Patient With Lung Adenocarcinoma With a ...
Gazdar A, Robinson L, Oliver D, et al. Hereditary lung · cancer syndrome targets never smokers with germline · EGFR gene T790M mutations. J ...
The vast majority of cases are associated with smoking. The strength of this association, however, varies according to genetic subtype. For example, the ...
What Women Need to Know About Lung Cancer | Penn Medicine
Shaking up stereotypes even further, approximately 20 percent of women diagnosed with lung cancer today are lifelong non-smokers (by contrast, ...
EGFR-Mutant Non–Small Cell Lung Cancer in the Era of Precision ...
Indeed, the T790M mutation was detected in the patient's whole blood, consistent with hereditary lung cancer syndrome. ... targets never smokers with germline ...
Hereditary lung cancer syndrome targets never smokers with germline ... Yamamoto H, Inherited lung cancer syndromes targeting never smokers. Transl ...
Lung Cancer Symptoms in People Who've Never Smoked
Experts at Yale Medicine stated that genetic mutations or irregularities usually cause lung cancer in non-smokers. Dr. Anne Chiang, thoracic ...
Identification of Genetic Mutations in Human Lung Cancer by ...
Roughly 34% of all lung ACs contain EGFR mutations, and these mutations are more common in non-smoking and Asian populations, with some studies ...
Beyond tobacco: genomic disparities in lung cancer between ...
However, about 10–20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences ...
The Personalized Inherited Signature Predisposing to Non ... - MDPI
Nevertheless, today, there is a need to better understand the genetic factors associated with lung cancer in never-smokers' patients in non-predisposed families ...
Lung Carcinoma - Merck Manual Professional Edition
Lung carcinoma is the leading cause of cancer-related death in men and women worldwide. About 85% of cases are related to cigarette smoking.
Pathogenic Germline Mutations Far More Common in Lung Cancer ...
... lung adenocarcinoma in never-smokers ... genetic testing vs guideline-directed targeted testing for patients with hereditary cancer syndrome.
Germline mutations and age at onset of lung adenocarcinoma
T790M, is associated with a hereditary lung cancer syndrome that affects predominantly female never smokers. TP53 is 1 of 12 genome maintenance ...
Targeting lung cancer screening to individuals at greatest risk
67 A multicentre study found that the risk of lung cancer increases with family history of the disease even among non-smoking women, providing further evidence ...
Lung cancer is also a hereditary disease
Approximately 10–15% of lung cancers in Western countries occur in never-smokers [1]. These cancers are accounted for by other occupational and ...
Activating Mutations in the Epidermal Growth Factor Receptor ...
A subgroup of patients with non–small-cell lung cancer have specific mutations in the EGFR gene, which correlate with clinical responsiveness to the tyrosine ...
Landscape of EGFR mutations in lung adenocarcinoma
EGFR mutation was identified in 55.7% of LUADs by PANAMutyper, with mutation rates higher in females (69.3%) and never smokers (67.1%) and ...
Why do never-smokers get lung cancer? - Cancer News
“Smokers can develop all types of lung cancers, although the association is stronger for small cell lung cancer and squamous cell carcinoma, ...
T790M in NSCLC: ESMO Biomarker Factsheet - OncologyPRO
In addition, a hereditary lung cancer syndrome with germline EGFR gene T790M mutations has been identified in approximately 1% of NSCLC cases, ...
Why are lung cancer rates rising in people who've never smoked?
Genomic sequencing looks for genetic mutations in cancer cells. This analysis is especially key in never-smokers because their tumors are often ...