Ligand|activated epidermal growth factor receptor

Epidermal growth factor (EGF) receptor-ligand based molecular ...

Increased expression of epidermal growth factor receptor (EGFR) and its ligands is associated with poor prognosis and chemoresistance in ...

Control of epidermal growth factor receptor endocytosis by receptor ...

We conclude that EGFR internalization is controlled by EGFR dimerization, rather than EGFR kinase activation.

Epidermal growth factor receptor-mediated innate immune ...

Thus, both activated eosinophils 37 and activated mast cells 40 have been shown to induce mucin synthesis in airway epithelial cells via the release of EGFR ...

Ligand-Induced Transformation by a Noninternalizing Epidermal ...

A mutant epidermal growth factor (EGF) receptor that does not undergo downregulation has provided a genetic probe to investigate the role of internalization in ...

Ligands of Epidermal Growth Factor Receptor and the Insulin-Like ...

Results. The effect of EGFR-TKIs treatment on DSS showed a significant difference by TGFa and ARG (interaction p = 0.046 and p = 0.004, respectively). Low ...

Activation of the epidermal growth factor receptor tyrosine protein ...

EGF and sphingosine stimulate the phosphorylation of an exogenous peptide substrate by the receptor to an equal extent. Chemical cross-linking using ...

Targeting Epidermal Growth Factor Receptor for Cancer Treatment

Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is activated by ligand binding, overexpression, or mutation. It is well ...

EGF receptor activation by G-protein coupled receptors

11. ... . Therefore, an alternative or additional means for EGF receptor transactivation may be through secondary autocrine activation, in which GPCR activation ...

Membrane Interaction of Bound Ligands Contributes to the Negative ...

Epidermal growth factor receptor (EGFR) molecules are of central importance in cellular communication. Embedded in the cell membrane, these receptors bind ...

Cooperative regulation of adherens junction expansion through ...

Upon junction formation, the activation of epidermal growth factor receptor (EGFR) ... ligand-independent activation of epidermal growth factor receptor . Am. J ...

Epidermal growth factor receptor juxtamembrane region regulates ...

This study demonstrates that the intracellular juxtamembrane (JM) region plays a vital role in the kinase activation mechanism.

Activating Mutations in the Epidermal Growth Factor Receptor ...

Most patients with non–small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which targets the epidermal growth factor ...

EGF (Epidermal Growth Factor) Receptor Ligands in Atrial Fibrillation

EGF (Epidermal Growth Factor) Receptor Ligands in Atrial Fibrillation: From Genomic Evidence to the Identification of New Players

Activation of the Epidermal Growth Factor Receptor in Macrophages ...

Activation of the epidermal growth factor receptor in macrophages regulates cytokine production and experimental colitis.

Inhibition of Epidermal Growth Factor Receptor Activation Is ...

Inhibition of epidermal growth factor receptor activation is associated with improved diabetic nephropathy and insulin resistance in type 2 diabetes.

Ligand-Induced Transformation by a Noninternalizing Epidermal ...

Ligand-Induced Transformation by a. Noninternalizing Epidermal Growth Factor Receptor. ALAN WELLS, JOHN B. WELSH, CHERI S. LAZAR, H. STEVEN WILEY,. GORDON N ...

EGFR Inhibitor Pathway, Pharmacodynamics - PharmGKB

... epidermal growth factor receptor specific tyrosine kinase inhibitors or monoclonal antibodies. ... ligand-induced receptor activation. The small molecule ...

Epidermal Growth Factor Receptor - YouTube

A New Look at the Conformational Change, Ligand Binding and Dimerization of the Epidermal Growth Factor Receptor.

QuickGO::Term GO:0045741

positive regulation of epidermal growth factor-activated receptor activity ... obsolete epidermal growth factor receptor activating ligand activity ...

The Epidermal Growth Factor Receptor and Its Ligands in ... - MDPI

Activation of EGFR has been implicated in blood pressure regulation, endothelial dysfunction, neointimal hyperplasia, atherogenesis, and cardiac remodeling.