MRE11|RAD50|NBS1 complex alterations and DNA damage ...

Modification in the Expression of MRE11/RAD50/NBS1 Complex in ...

These effects consequently protected cells from gene mutation, DNA damage and chromosomal aberrations caused by subsequent exposure to radiation (Wang and Cai ...

The molecular mechanisms of the Mre11/Rad50 DNA repair complex

We hypothesize that the slow exonuclease activity originates from MR complexes where two Mre11 complexes are bound to the Rad50 dimer, but the ...

ATM and the Mre11-Rad50-Nbs1 Complex Respond to Nucleoside ...

Abstract. The Mre11-Rad50-Nbs1 complex and autophosphorylated Ser1981-ATM are involved in recognizing and repairing DNA damage, ...

Rad17 recruits the MRE11‐RAD50‐NBS1 complex to regulate the ...

The MRE11‐RAD50‐NBS1 (MRN) complex is essential for the detection of DNA double‐strand breaks (DSBs) and initiation of DNA damage signaling.

DNA repair protein RAD50 - Homo sapiens (Human) | UniProtKB

RAD50 provides an ATP-dependent control of MRE11 by positioning DNA ends into the MRE11 active site: ATP-binding induces a large structural change from an open ...

The Mre11/Rad50/Nbs1 Complex Limits Adeno-Associated Virus ...

The Mre11 complex is implicated as a major sensor of DNA damage in the cell, recognizing structures such as double-strand DNA ends, single-strand DNA, and ...

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...

Abstract. Background: The MRN complex of meiotic recombination 11 (MRE11), DNA repair protein Rad50. (RAD50) and Nijmegen breakage syndrome 1 (NBS1).

A Mutant Allele of MRE11 Found in Mismatch Repair-deficient ...

The interaction of ataxia-telangiectasia mutated (ATM) and the Mre11/Rad50/Nbs1 (MRN) complex is critical for the response of cells to DNA double-strand ...

Aberrations of the MRE11–RAD50–NBS1 DNA damage sensor ...

Sequencing the RAD50, MRE11 and NBS1 genes of 8 patients from non-BRCA1/2 breast cancer families whose tumours showed concomitant reduction/loss ...

Intact Mre11/Rad50/Nbs1 Complex Predicts Good Response to ...

15. Angele, S. ∙ Treilleux, I. ∙ Bremond, A. ... Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas.

The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of ...

Genomic instability in disease and its fidelity in health depend on the DNA damage response (DDR), regulated in part from the complex of meiotic ...

Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular ...

Current advances in the molecular analysis of DNA damage responses have shown that the auto-phosphorylation of ATM and the interaction between ATM and NBS1 are ...

Molecular disruption of RAD50 sensitizes human tumor cells to ... - JCI

An enhanced DNA repair and telomere maintenance response by the Mre11/Rad50/Nbs1 (MRN) complex is critical in driving this chemoresistance. We ...

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor ...

Background: The MRN complex of meiotic recombination 11 (MRE11), DNA repair protein Rad50 (RAD50) and Nijmegen breakage syndrome 1 (NBS1) proteins coordinate ...

Turning the Mre11/Rad50 DNA repair complex on its head

DNA double-strand breaks (DSBs), where both strands of the DNA duplex are concurrently broken, represent some of the most cytotoxic forms of ...

Importin KPNA2, NBS1, DNA Repair and Tumorigenesis

MRE11–RAD50–NBS1 complex can no longer be viewed as having a single role in DNA damage repair since it also serves as a sensor and a mediator in ...

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity ...

The multifunctional Mre11-Rad50-Nbs1 (MRN) protein complex recruits ATM/Tel1 checkpoint kinase and CtIP/Ctp1 homologous recombination (HR) repair factor to ...

Nbs1 Mediates Assembly and Activity of the Mre11 complex - bioRxiv

The Mre11 complex, composed of Mre11, Rad50, and Nbs1 is a sensor of DNA double-strand breaks (DSBs) and is required for the activation of the ...

Nbs1 | Sigma-Aldrich

Stable maintenance of the Mre11-Rad50-Nbs1 complex is sufficient to restore the DNA double-strand break response in cells lacking RecQL4 helicase activity.

MRN complex function in the repair of chromosomal Rag-mediated ...

The Mre11–Rad50–Nbs1 (MRN) complex functions in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) at ...