Metabolic reprogramming in inflammaging and aging in T cells

Effects of Aging on Metabolic Characteristics of Human B Cells - OUCI

Although preliminary, these results suggest the intriguing possibility that metabolic pathways can represent potential novel therapeutic targets to reduce ...

T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse ...

Altogether, these data indicate that T cell-specific miRNAs play pivotal roles in regulating lifespan through their influences on inflammaging. Many UC-authored ...

Defective respiration and one-carbon metabolism contribute ... - PNAS

Rewiring of intracellular metabolism is key for T cell activation and effector functions, but the metabolic changes in T cells during aging are ...

TNF-α signals through ITK-Akt-mTOR to drive CD4+ T cell metabolic ...

Together, these findings suggest that T cell–derived TNF-α drives their metabolic reprogramming by promoting signaling through ITK, Akt, and ...

Recent developments and future perspectives in aging ... - AIMS Press

... inflammation (inflammaging) and decreases in immune function (immunosenescence). Metabolic reprogramming in immune cells is a significant ...

Role of Myeloid Cells in Age-Related Diseases

Aging progressively undermines this ability and compromises the correct activation of immune responses, as well as the resolution of the ...

Macrophage function in the elderly and impact on injury repair and ...

This rise in age-related diseases/co-morbidities is associated with changes to immune function, including in myeloid cells, and is related to ...

Microenvironmental stiffness induces metabolic reprogramming in ...

... cells can affect the metabolism and invasive behavior of brain cancer cells ... This content isn't available. In this episode of Research ...

Age-associated changes in human CD4 + T cells point to ...

The crux of our model is that decreased capacity to clear dysfunctional mitochondria through autophagy with age and contributes to increased oxidative stress [ ...

"T cells as drivers of senescence and aging" by Dr. Maria Mittelbrunn

Mitochondria, Aging, and Health. Kinexum Services LLC•40K views · 1:03:45 · Go to channel · Vittorio Sebastiano | Epigenetic Reprogramming of ...

Because senescent cells are produced in response to metabolic stress and accumulate during aging, they are thought to play a key role in the ...

Inflammation at the nexus of metabolism, aging, and cognition

This content isn't available. This event is presented by Sarah Elzinga, Ph.D. Inflammation at the nexus of metabolism, aging, and cognition.

Review discusses metabolic reprogramming of T cells

Exhausted T cells have idiosyncratic metabolic demands and are plagued by ineffective mitochondria and glycolytic cycles. Improving T cell ...

Scientists reprogram T cells to slow down and reverse aging in 2024

... metabolism and glucose tolerance, and increased physical ... inflammation, rendering the aging immune system less effective over time.

The 2024 Levels Guide to understanding your cholesterol panel and ...

... inflamm-aging”), and other inflammatory conditions. ... Dr. Means: Inflammation is a key driver of metabolic dysfunction, and metabolic ...

How Does Reprogramming Affect Senescent Cells & Inflammation?

Go to channel · Eric Verdin - NAD+ metabolism as a link between senescence and metabolic impairment during aging. ARDD•8.7K views · 26:21.

Sarcopenia - Wikipedia

Sarcopenia is a type of muscle loss that occurs with aging and/or immobility. It is characterized by the degenerative loss of skeletal muscle mass, quality, ...

Inflammaging: a new immune–metabolic viewpoint for age-related ...

From an evolutionary perspective, a variety of stimuli sustain inflammaging, including pathogens (non-self), endogenous cell debris and ...

LPS Drives CD38 Expression | Prof Covarrubias Interview Series Ep5

E122 James Kirkland on targeting senescent cells to reverse age ... David Sinclair on the Brink of Anti-Aging: Reprogramming Cells for Eternal ...