Noncoding RNAs and RNA Editing in Brain Development ...

Non-coding RNAs with essential roles in neurodegenerative disorders

ncRNAs are involved in neuronal cell specification and patterning during development, but also in higher cognitive processes, such as structural plasticity and ...

Non-coding RNAs with essential roles in neurodegenerative disorders

Noncoding RNAs and RNA editing in brain development, functional diversification, and neurological disease. M. MehlerJ. Mattick. Medicine, Biology.

Rapid and dynamic transcriptome regulation by RNA editing and ...

... RNAs—mostly mRNAs but also noncoding RNAs ... Large-scale mRNA sequencing determines global regulation of RNA editing during brain development .

Finding Function for Noncoding RNAs Using a New Kind of CRISPR

Using CRISPR technology that targets RNA instead of DNA, researchers at New York University and the New York Genome Center searched across the ...

innovative CRISPR approaches for functional studies of long non ...

Functional lncRNA knockouts could be generated using CRISPRn excision, by either deleting the target lncRNAs promoters [61, 63–66] or deleting ...

Long Noncoding RNA-Directed Epigenetic Regulation of Gene ...

RNA sequencing was used to identify changes in the experience-dependent expression of long noncoding RNAs (lncRNAs) within the medial prefrontal cortex of ...

RNA Editing in Pathogenesis of Cancer - AACR Journals

miRNAs are small noncoding RNAs that play an important role in posttranscriptional gene regulation by silencing gene expression. RNA editing of ...

A-to-I RNA editing of CYP18A1 mediates transgenerational wing ...

0 with an E-value cutoff of 10-5 to identify other types of noncoding RNAs (ncRNAs) (80). Protein-coding genes were predicted through the ...

Long Non-coding RNAs Associated with Brain Disorders - Brieflands

A well-known lncRNA is MALAT1 that is committed to regulating neurite growth. MALAT1 is found in several tissues; however, it is concentrated in nerve cells.

Finding function for noncoding RNAs using a new kind of CRISPR

Using CRISPR-Cas13 to edit RNA and avoid off-target activity, the researchers systematically profiled nearly 6,200 gene pairs of long noncoding ...

The functional role of long non-coding RNAs and epigenetics

Recent findings reveal that lncRNAs are implicated in serial steps of cancer development [113]. These lncRNAs interact with DNA, RNA, protein ...

Gene and RNA Editing: Methods, Enabling Technologies ... - arXiv

Gene editing modifies DNA strands within an individual's genome with a cut and deletion of the mutation, while RNA editing sends a messenger to ...

The functions of long noncoding RNAs in development and stem cells

The dissection of lncRNA mechanisms typically requires the identification of protein, DNA and RNA binding partners. Biotinylated RNA transcribed ...

A brief review of noncoding RNA

Coding RNA generally refers to mRNA that encodes protein, noncoding RNAs Â act as cellular regulators without encoding proteins.

Non-Coding RNA in Brain Development and Disorder - Eurekaselect

Summary: Recent evidence has shown that ncRNAs are abundantly expressed in the brain and many of them are aberrantly regulated in neural disorders. Yet their ...

Noncoding RNAs in the Brain - Journal of Neuroscience

ncRNAs in neuronal development and brain evolution. There have ... Mehler MF, Mattick JS (2007) Non-coding RNAs and RNA editing in brain.

Full article: The emerging RNA-centric world of neurobiology

These studies have resulted in close examination of the role of coding and noncoding RNAs in neurons, and they have led to an explosive ...

Manipulation of Long Non-coding RNAs in Cardiovascular Disease ...

The traditional view on non-coding RNA (ncRNA) as “junk of the genome” has been revolutionized to how we view eukaryotic genome complexity.

RNA Editing in Brain Health and Disease - YouTube

RNA editing catalyzed by adenosine deaminases acting on RNA (ADARs) occurs naturally at thousands of sites across the human transcriptome.

RNA-targeting CRISPR reveals that hundreds of noncoding RNAs ...

Most CRISPR applications use an enzyme called Cas9 to edit genes on the DNA level. However, a newer technology uses the enzyme Cas13 to more ...