Pharmacologic IRE1/XBP1s activation promotes systemic adaptive ...

The IRE1α pathway in glomerular diseases: The unfolded protein ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nat. Commun. 13 (1), 608. doi:10.1038/s41467-022-28271-2. PubMed ...

ATP-competitive partial antagonists of the IRE1α RNase segregate ...

Low-level activation of the IRE1α kinase/RNase promotes cleavage of the adaptive XBP1 transcription factor mRNA ... Pharmacologic IRE1/XBP1s activation confers ...

ER Ca2+ overload activates the IRE1α signaling and promotes cell ...

... promote IRE1α overactivation and XBP1 splicing ... Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity.

‪Aparajita Madhavan‬ - ‪Google Scholar‬

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. A Madhavan, BP Kok, B Rius, JMD Grandjean, A Alabi, V Albert, ... Nature ...

Small molecule strategies to harness the unfolded protein response

IRE1 also promotes signaling independent of its RNase activity. ... 85. Grandjean, J.M.D. ∙ Madhavan, A. ∙ Cech, L. ... Pharmacologic IRE1/XBP1s activation ...

Activation Signal of Nuclear Factor-κB in Response to Endoplasmic ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. ... The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress ...

Divergent Proteome Reactivity Influences Arm-Selective Activation ...

Pharmacological activation of the activating transcription factor 6 (ATF6) arm of the unfolded protein response (UPR) has proven useful for ...

‪Andrea Galmozzi‬ - ‪Google Scholar‬

2017. Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. A Madhavan, BP Kok, B Rius, JMD Grandjean, A Alabi, V Albert ...

Endotoxemia-mediated activation of acetyltransferase P300 impairs ...

... promotes insulin resistance in mice. Here, we show that LPS ... HFD feeding led to the activation of the IRE1-XBP1 pathway and the generation of XBP1s.

Targeting IRE1 with Small Molecules Counteracts Progression of ...

Activation of the unfolded protein response (UPR), a homeostatic regulatory network that responds to ER stress, is a hallmark of all stages of atherosclerotic ...

Targeting IRE1 with small molecules counteracts progression of ...

Disruption of any of these functions leads to ER stress and the subsequent activation of an elaborate network of adaptive responses, collectively known as the ...

Novel XBP1s-independent function of IRE1 RNase in HIF-1α ...

Once activated, IRE1 can induce three kinds of signaling pathways. IRE1 RNase activity promotes non canonical splicing of XBP1 mRNA that produces the adaptive ...

Molecular Mechanism Underlying Role of the XBP1s in ... - MDPI

... XBP1s-mediated mTOR activation and adaptive cell proliferation [73]. Another study came to the significant conclusion that XBP1s promotes cardiac ...

The Unfolded Protein Response: Integrating Stress Signals Through ...

The functional synergy demonstrated between TLR activation and classic pharmacological stressors like tunicamycin in IRE1 ... ACTIVATION OF THE IRE1/XBP1 PATHWAY ...

The Structure, Activation and Signaling of IRE1 and Its Role in ...

Apart from the unconventional XBP1 mRNA splicing, IRE1 promotes ... Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis ...

Deconvoluting Stress-Responsive Proteostasis Signaling Pathways ...

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Nature Communications 2022, 13 (1) https://doi.org ...

Genomic targets of the IRE1-XBP1s pathway in mediating metabolic ...

Here, the inositol-requiring protein 1 (IRE1α)–X-box-binding protein 1 (XBP1) arm of the UPR is selectively activated. (11) by the rapid influx ...

Genome-wide mRNA profiling identifies X-box-binding protein 1 ...

As previously mentioned, XBP1s mRNA results from ER stress-activated IRE1 ... (XBP1) expression during the adaptive phase of the unfolded ...

IRE1 Inhibitor III, 4μ8C - Sigma-Aldrich

Pharmacologic IRE1/XBP1s activation promotes systemic adaptive remodeling in obesity. Aparajita Madhavan et al. Nature communications, 13(1), 608-608 (2022 ...

Pharmacological Targeting of IRE1 in Cancer

Indeed, the activation of IRE1 signaling under low ER stress promotes autophagy and cell survival through an XBP1s mechanism. However, it has been described ...