Prevalence of Germline Variants in Prostate Cancer and ...

Prevalence of germline BRCA1/2 pathogenic variants in Japanese ...

in prostate cancer. Overall survival from castration-resistant prostate cancer for patients with. BRCA1/2 variants was significantly shorter ...

Germline Mutations in African American Men With Prostate Cancer

The importance of germline variants of uncertain significance (VUS) remain poorly elucidated and given the elevated rates of VUS in AAM compared to Caucasians ...

Germline variants in early and late-onset Brazilian prostate cancer ...

List of references. Sung, Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J ...

Germline Variants in DNA Damage Repair Genes and HOXB13 ...

RESULTS: Among 743 Black prostate cancer patients, we identified 26 unique pathogenic (P) or likely pathogenic (LP) variants in 14 genes (including HOXB13, ...

Prevalence of pathogenic germline variants in 779 patients with ...

Between 3 and 19% of mPC patients were shown to have a PV in the DNA damage repair genes BRCA2, CHEK2 and ATM, and to a lesser extent, BRCA1 and ...

Germline DNA Repair Genes Pathogenic Variants Among Mexican ...

We describe the frequency of DNA repair gene pathogenic variants among Mexican men with prostate cancer. We found a low prevalence of known ...

Germline testing in those at risk of prostate cancer

Prevalence of germline variants in prostate cancer and implications for current genetic testing guidelines. JAMA Oncol 2019;5(4):523-528. 5. Pritchard CC ...

Germline variants in early and late-onset Brazilian prostate cancer ...

Results: A higher frequency of variants in the BRCA2 and KMT2C genes across both age groups. KMT2C has been linked to the epige- netic dysregulation observed ...

Recent Insights on Genetic Testing in Primary Prostate Cancer

Despite improved understanding of the prevalence of pathogenic variants among men with PCa, it remains unclear which men will most benefit from ...

Gene-based Confirmatory Germline Testing Following Tumor-only ...

Of the 1883 patients identified, 1084 (58%) had a somatic or germline pathogenic variant in one of 60 cancer susceptibility genes, and of them, ...

Germline Variants and Risk of Aggressive Prostate Cancer

Carrier frequency for deleterious NBN alleles was 0.5% in metastatic cases (OR = 5.16, 95% CI = 2.19–12.12, P = 1.7 × 10−4) compared with 0.2% ...

Understanding the prevalence of germline oncogenic biomarker ...

Traditionally, germline variants in cancer have been studied mainly as predisposition ... Prostate Cancer, NOS, Prostate. Cancer. BARD1 p ...

Germline and Somatic Mutations in Prostate Cancer for the Clinician in

For germline BRCA2 mutation carriers, the relative risk of developing prostate cancer by age 65 years is estimated to be 2.5- to 8.6-fold compared with ...

Prevalence of germline BRCA1/2 pathogenic variants in Japanese ...

In total, 6.5% of patients carried the germline BRCA1/2 pathogenic variants, exhibiting poor prognosis and poor clinical response to ...

Prevalence of pathogenic or likely pathogenic germline variants in ...

The main PGVs were in ATM (9.3 %), TP53 (6.9 %), BRCA2 (6.9 %), and CHEK2 (6.9 %) genes. PGVs were associated with male sex (adjusted odds ratio [aOR] 2.46, 95 ...

Prevalence of pathogenic germline cancer risk variants in high-risk ...

MSH2 (34/969, 3.5%) and BRCA1/2 (38/867, 4.4%) germline variants had the highest frequency. Germline variants in DNA damage repair genes accounted for 78% of ...

The prevalence of lynch syndrome (DNA mismatch repair protein ...

Prostate cancer is one of the most heritable human cancers. Lynch syndrome is an autosomal dominant inheritance caused by germline mutations in ...

A prospective prostate cancer screening programme for men with ...

The IMPACT study is prospectively assessing prostate-specific antigen (PSA) screening in men with germline mismatch repair pathogenic variants.

Germline Mutations in HOXB13 and Prostate-Cancer Risk

The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.

Germline testing study's implications for veteran access to prostate ...

Of the 76 total men evaluated in the study, 18 (23.7%) were found to have a VUS, and 1 (1.32%) had a pathogenic germline variant in the BRCA1 ...