Progress in the Development of Preventative Drugs for Cisplatin ...

Mechanisms of Cisplatin Nephrotoxicity - MDPI

... cisplatin nephrotoxicity and discusses how these advances might lead to more effective prevention ... These agents are in clinical development for cancer ...

Hydration Methods for Cisplatin Containing Chemotherapy

Cisplatin-induced nephrotoxicity (CIN) can be prevented by fluid hydration, electrolyte supplementation, or forced diuresis; however, ...

Cisplatin and beyond: molecular mechanisms of action and drug ...

Although many cancer cells are initially susceptible to chem- otherapy with platinum drugs, over time they may develop resistance through more efficient DNA.

Cisplatin-induced nephrotoxicity in children: what is the best ...

Available data has shown that pre- and post-hydration have been the main preventive strategies adopted when planning for cisplatin infusion due ...

Cancer Progress Timeline | ASCO

Sodium Thiosulfate Helps Reduce Risk of Cisplatin-Induced Hearing Loss ... While cisplatin chemotherapy and surgery are effective treatments for children with ...

Systems biology of cisplatin resistance: past, present and future

Such an experimental effort culminated in 1978 with the approval of CDDP by the US Food and Drug Administration (FDA) for use in testicular and ...

Cisplatin - Drug Targets, Indications, Patents - Patsnap Synapse

Cisplatin: a DNA inhibitors Drug, Initially developed by HQ Specialty Pharma Corp., Now, its global highest R&D status is Approved, ...

Cisplatin dosing, indications, interactions, adverse effects, and more

It is a chemotherapy drug that contains platinum. It is used to slow or stop cancer cell growth. HOW TO USE: This medication is usually given by injection into ...

Review of the toxicological mechanism of anticancer drug cisplatin

Herein, we discuss the discovery process of cisplatin, the development of the platinum drugs, toxicology on mechanism of cisplatin and the ...

Cisplatin - Together by St. Jude™

It works by slowing or stopping the growth of cells. Cisplatin is usually used in combination with other medicines. Patients will have regular blood tests to ...

Transtympanic injections to prevent hearing loss caused by cisplatin

What remains to be decided is the mode, timing, dose and method of administration of the otoprotectant drugs without them interfering with the ...

Sensorion to Continue Trial for Ototoxicity Drug Candidate

Sensorion was recommended to continue the study of a drug candidate for the prevention of Cisplatin-Induced Ototoxicity (CIO).

cisplatin injection - accessdata.fda.gov

Consider alternative treatments or reduce the dose of cisplatin for injection for patients with baseline renal impairment or who develop significant reductions ...

Nausea and Cisplatin Chemotherapy - PRIMR

What if you experience nausea during treatment, even though you're using preventative medication? ... progress. Related Education. The ...

Development of Second-Generation CDK2 Inhibitors for the ...

Hazlitt RA; Min J; Zuo J Progress in the development of preventative drugs for cisplatin-induced hearing loss. J. Med. Chem 2018, 61, 5512–5524. [PubMed ...

Cisplatin-based Liposomal Nanocarriers for Drug Delivery in Lung ...

These novel formulations show promise in reducing cisplatin resistance, optimizing pharmacokinetics, and boosting therapeutic results in the two ...

Overcoming Cisplatin's Challenges: A Promising Future in Cancer ...

Conclusion: Cisplatin is a potent anticancer tool marked by challenges from adverse effects and emerging resistance. Ongoing research focuses on ...

Cisplatin-Based Adjuvant Chemotherapy in Patients with ...

Both thoracic radiotherapy and prophylactic brain irradiation result in a survival benefit of 5.4 percent at three years in patients with small-cell lung cancer ...

Prevention of chemotherapy-induced nausea and vomiting in adults

Cisplatin and other highly emetogenic single agents · Anthracycline ... Significant progress has been made, but CINV remains an important adverse ...