Proposed mechanism of LPA signaling in osteoclasts. LPA is ...

LPA Is a Chemorepellent for B16 Melanoma Cells - PLOS

Our results define LPA5 as an anti-migratory receptor and they implicate the cAMP-PKA pathway, along with reduced PIP3 signaling, as an effector of ...

The Role of Lysophosphatidic Acid in Adult Stem Cells

LPC is an intermediate in multiple lipid metabolic pathways. These results suggest the distinct signaling mechanisms of LPA receptors are ...

Bone defects in LPA receptor genetically modified mice - OUCI

Lapierre, Lysophosphatidic acid signals through multiple receptors in osteoclasts ... Swarthout, Parathyroid hormone-dependent signaling pathways regulating genes ...

Lysophospholipid (LPA) receptors | G protein-coupled receptors

Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [3,17,28,43]) are activated by the ...

Prime Targets for Mitigating Therapy Resistance in Breast Cancer ...

LPA signaling through six G-protein-coupled LPA receptors expressed by cancer cells can then activate virtually every known tumorigenic pathway. Consequently, ...

The lysophosphatidic acid-regulated signal transduction network in ...

LPA is known to support metastatic spread of cancer cells by activating a multitude of signaling pathways via G-protein-coupled receptors of the LPAR family.