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Regulation of tissue iron homeostasis


Mechanisms of Mammalian Iron Homeostasis - ACS Publications

Mammalian cells utilize multiple mechanisms to acquire iron. ... Mammals utilize distinct mechanisms to regulate iron homeostasis at the systemic and cellular ...

Iron metabolism and its contribution to cancer (Review)

Iron has dual properties, which may facilitate tumor growth or cell death. Cancer cells exhibit an increased dependence on iron compared with ...

Iron homeostasis in plants – a brief overview - Oxford Academic

On the other hand, excess iron is toxic to cells. Therefore, organisms have evolved intricate mechanisms to take up, metabolise and store iron, and regulate ...

Hepcidin, an emerging and important player in brain iron homeostasis

Tight junctions between these cells preclude an iron-entry through paracellular pathways, leaving the option of transcellular pathway as the ...

Current understanding of iron homeostasis

At the whole-body level, dietary iron absorption and iron export from the tissues into the plasma are regulated by the liver-derived peptide hepcidin. When ...

Hypoxia-Inducible Factors Link Iron Homeostasis and Erythropoiesis

One compo- nent of this pathway, hypoxia-inducible factor (HIF), is a transcription factor that is highly active in hypoxic cells. The first HIF target gene ...

Nitric oxide–mediated regulation of ferroportin-1 controls ...

Cellular iron homeostasis in macrophages is regulated at multiple steps and by numerous genes (Weiss, 2009). Macrophages can acquire iron by ...

Central role for ferritin in the day/night regulation of iron homeostasis ...

Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of ...

Control of iron homeostasis as a key component of macrophage ...

9 Iron retention in the reticuloendothelial system is a well characterized response of body iron homeostasis to inflammation, as a host's ...

from iron-deficiency anemia to hereditary hemochromatosis - YouTube

Iron homeostasis and its disorders: from iron-deficiency anemia to hereditary hemochromatosis. 10K views 8 years ago

Iron homeostasis: transport, metabolism, and regulation

Senescent red cells are destroyed by macrophages and their iron is released to re-join the plasma iron pool. The master iron regulatory hormone hepcidin is.

Questions and Answers about Iron Homeostasis | Chemical Reviews

Iron and oxygen homeostasis, in animals, integrate DNA/mRNA controls; regulation of these two processes intersect along many pathways. Iron ...

Iron Physiology - YouTube

Iron Metabolism : Transportation and Storage, Absorption and Regulation, Daily loss of iron : USMLE Dr.G Bhanu Prakash Animated Medical Videos

Iron Metabolism : Transportation and Storage, Absorption ... - YouTube

Iron Metabolism : Transportation and Storage, Absorption and Regulation, Daily loss of iron ... iron occurs through shedding of epithelial cells ...

IL6 - Interleukin-6 - Homo sapiens (Human) | UniProtKB | UniProt

Plays a protective role during liver injury, being required for maintenance of tissue regeneration (By similarity). Also has a pivotal role in iron metabolism ...

Hemoglobin - Wikipedia

In these tissues, hemoglobin absorbs unneeded oxygen as an antioxidant, and regulates iron metabolism. ... Excessive glucose in the blood can attach to hemoglobin ...

Erythropoiesis: What It Is & Process Stages - Cleveland Clinic

Your kidneys detect an increase in hemoglobin, a key protein in red blood cells, and secrete less EPO in response. Your body achieves a balance (homeostasis) ...

Iron Absorption, Transport, Metabolism and Regulation - YouTube

Medicine/Biochemistry lesson on iron absorption, transport in the blood, metabolism and regulation of iron uptake in the body.

Regulation of iron homeostasis by the hypoxia-inducible ...

Iron is essential for many biological processes, including oxygen delivery, and its supply is tightly regulated. Hepcidin, a small peptide synthesized in ...

The physiological functions of iron regulatory proteins in ... - YouTube

... iron regulatory proteins in iron homeostasis - an update Authors: De-Liang eZhang, Manik C. Ghosh ,and Tracey A. Rouault Publisher ...