Reprogramming of host energy metabolism mediated by the TNF ...

Full article: Oxygen and metabolic reprogramming in the tumor ...

... host. Clinically the ... Oxidized ATM promotes breast cancer stem cell enrichment through energy metabolism reprogram-mediated acetyl-CoA accumulation.

Reprogramming of Lipid Metabolism Mediates Crosstalk ...

Sphingodylcholine (SPC), a lipid mediator present in the blood, mediates both autophagy and apoptosis in TNBC cell lines; however, autophagy acts as a negative ...

Energy Metabolism Pathways in Stem Cell Fate Regulation - [v1]

NRF2 activates HIF1α through TRX1, and HIF2α upregulates the expression of TNF related apoptosis inducing ligand (TRAIL) in the late stage of ...

The Drosophila tumor necrosis factor receptor, Wengen, couples ...

These observations show that Wgn/TNFR functions as metabolic switch reprogramming metabolism toward energy expenditure in conditions associated ...

Modulation of Mitochondrial Metabolic Reprogramming and ... - MDPI

This is also realized through the function of specific stress-adaptive proteins, which are able to relieve oxidative stress, inhibit apoptosis, and facilitate ...

Epithelial metabolism as a rheostat for intestinal inflammation and ...

... host and gut microbes by creating a ... al.: Aldolase B-mediated fructose metabolism drives metabolic reprogramming of colon cancer liver metastasis.

Metabolic reprogramming and cancer precision medicine

On one hand, increased myeloid cell-derived ROS and TNF-α mediated signaling can lead to epithelial mutagenesis and carcinogenesis (26). ROS can affect GAPDH, ...

Metabolic reprogramming in inflammaging and aging in T cells

However, during aging, the immune system progressively loses its ability to protect the host against diseases. ... KL. TSC2 mediates cellular energy response to ...

Silibinin-mediated metabolic reprogramming attenuates pancreatic ...

Cachexia is a complex disorder that results from tumor-host interplay and metabolic alterations causing increased energy expenditure ...

Metabolic reprogramming of cancer-associated fibroblasts and its ...

The crosstalk between cancer cells and CAFs is associated with cell metabolic reprogramming that contributes to cancer cell growth, progression, and evasion ...

Conserved metabolic energy production pathways govern Eiger ...

In this paper, we provide genetic evidence that metabolic energy production-related molecules are central to the Eiger/TNF-induced cell death ( ...

Mechanisms of Metabolic Reprogramming in Cancer Cells ...

It also has the potential to contribute to ATP regeneration via MTHFD1L-mediated reaction that produces formate, which can cross the mitochondrial membrane and ...

Changes in Energy Metabolism - Promega Corporation

Within the tumor microenvironment, changes in metabolite levels often result in altered immunometabolic pathways of T cells and other immune cells. Tumor cells ...