SPRTN protease and checkpoint kinase 1 cross|activation loop ...

Characterization of SPRTN, the first mammalian metalloprotease ...

... SPRTN to the DPC or activating its proteolytic ... SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication.

DoUBLing up: ubiquitin and ubiquitin-like proteases in genome ...

One mechanism to remove DNA-protein cross-links (DPCs) is through the DNA-dependent metalloprotease SPRTN whose activity requires removal of an inhibitory mono- ...

(PDF) DNA-activated Protein Kinase Functions in a Newly

SPRTN Protease and Checkpoint Kinase 1 Cross-Activation Loop Safeguards DNA Replication. Nature Communications · Astronomy Genetics Molecular Biology ...

DNA–Protein Cross-Links: Formation, Structural Identities, and ...

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nature Communications 2019, 10 (1) https://doi.org ...

Cellular responses to nucleic acid-protein crosslinks

SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nat Commun 10, 3142. Han, J., Back, S.H., Hur, J ...

DNA-dependent metalloprotease SPRTN - Mus musculus (Mouse)

DNA-dependent metalloendopeptidase that mediates the proteolytic cleavage of covalent DNA-protein cross-links (DPCs) during DNA synthesis, thereby playing a ...

SPRTN is a mammalian DNA-binding metalloprotease that resolves ...

SPRTN is a protease essential for the repair of cytotoxic DNA-protein cross ... SPRTN-∆C1–216 protein in this EMSA assay. This result ...

Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and ...

HpaII species slowly appeared (Figure 1B, lane 6). These species were cleaved by the SUMO protease Ulp1 (data not shown), and their appearance ...

SPRTN Gene - GeneCards | SPRTN Protein | SPRTN Antibody

Acts as a pleiotropic protease for DNA-binding proteins cross-linked ... 1 diseases for SPRTN Gene - From: OMIM®, ClinVar, Orphanet ...

Mechanism and Regulation of DNA-Protein Crosslink Repair by the ...

SPRTN/Wss1 proteases bear interaction domains for p97/Cdc48 (SHP-box, VIM), recognition modules for ubiquitin (UBZ) or SUMO (SIM), and in ...