Single|cell analysis of the earliest cell fate decisions in development

Deciphering Cell Fate Decision by Integrated Single-Cell ... - SSRN

A comprehensive understanding of the regulatory mechanisms of cell fate choices during development, regeneration, homeostasis, and disease is a ...

Single‐cell analyses to reveal hematopoietic stem cell fate decisions

Another recently developed approach to investigate single-cell gene expression is CytoSeq, which was first applied to characterize heterogeneous ...

Mechanically guided cell fate determination in early development

We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. ... cell fate decisions. Certainly, ...

Cell Fate Decisions - latest research news and features - Phys.org

The Spatial Mouse Atlas: New insights into cell fate. Sep 7, 2021. Single-cell analysis of the earliest cell fate decisions in development. Dec 11, 2019 ...

Single-cell Transcriptome Profiling reveals Dermal and Epithelial ...

Single-cell Transcriptome Profiling reveals Dermal and Epithelial cell fate decisions during Embryonic Hair Follicle Development ... Taken together, our analysis ...

Using Single-Cell and Spatial Transcriptomes to Understand Stem ...

Embryonic development and stem cell differentiation provide a paradigm to understand the molecular regulation of coordinated cell fate determination and the ...

Understanding cell fate control by continuous single-cell quantification

... analysis of cells at different developmental stages or cell ... Decoding the regulatory network of early blood development from single-cell gene ...

Dynamical landscapes of cell fate decisions | Interface Focus

The generation of cellular diversity during development involves differentiating cells transitioning between discrete cell states.

Path to building an entire organism from single cell is revealed

Harvard research teams systematically profiled every cell in developing zebrafish and frog embryos to establish a roadmap revealing how one ...

Early Cell Fate Decisions of Human Embryonic Stem Cells ... - PLOS

Importantly, these defined culture conditions are devoid of factors that could obscure analysis of developmental mechanisms or render the resulting tissues ...

The chromatin accessibility dynamics during cell fate specifications ...

In zebrafish, recent single-cell RNA-seq (scRNA-seq) developmental atlases provided gene expression overviews of all major cell types from embryonic to adult ...

Cell-fate decisions in early T cell development: regulation by ...

2000. TLDR. The present study was performed to analyze the gene expression profile during T-cell development, in particular, during the differentiation of ...

Single-cell analysis reveals key roles for Bcl11a in regulating stem ...

Single-cell analysis reveals key roles for Bcl11a in regulating stem cell fate decisions ... developing systems. Heterogeneity in HSCs.

Defining multistep cell fate decision pathways during pancreatic ...

Synopsis Combining genetic lineage tracing and single‐cell gene expression analyses, this resource deciphers the multistep trajectories of endocrine and ...

Unravelling cell fate decisions through single cell methods and ...

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised ...

Cell Fate Decisions Within the Vascular Cambium–Initiating Wood ...

Especially in tissues with non-stereotypic anatomies, dynamic communication between developing cells is vital for ensuring functional tissue ...

Understanding cell fate decisions in early mammalian development

During early mammalian development, a plethora of diverse cell types arises from a single layer of epiblast cells within a short window of time.

John Marioni, Using Single Cell Genomics to Understand ... - YouTube

... early development, for example, there are only a small number of cells, each of which can have a distinct function and role. As cell fate ...

A multiscale model via single-cell transcriptomics reveals robust ...

At the earliest stages of embryo development, cells make robust fate decisions ... decisions revealed by single-cell gene expression analysis ...

scRNA-sequencing in chick suggests a probabilistic model for cell ...

By focusing on one of the earliest cell fate decisions in the ectoderm of a vertebrate embryo, this study will be valuable to a broad range of developmental ...