Small Interfering RNA

Small Interfering RNAs Mediate Sequence-Independent Gene ...

The use of siRNA, delivered by expression constructs or directly as a treatment for numerous diseases, has been proposed. The observation that these ...

Application of Small Interfering RNAs to Gastrointestinal Diseases

RNA interference (RNAi) is a naturally occurring cellular mechanism wherein foreign double-stranded RNA introduced into the cell induces posttranscriptional ...

Delivery of Small Interfering RNA by Peptide-Targeted Mesoporous ...

Protocells have a 10- to 100-fold greater capacity for siRNA than corresponding lipid nanoparticles and are markedly more stable when incubated under ...

Small Interfering RNA Targeting M2 Gene Induces Effective ... - PLOS

The results showed that a siRNA targeting influenza M2 gene (siM2) potently inhibited viral replication. The siM2 was not only effective for H1N1 virus but also ...

Small interfering RNA (siRNA) biogenesis - Reactome

Small interfering RNA (siRNA) biogenesis. Stable Identifier. R-MMU-426486. Type. Pathway.

RNAi Therapeutics | How RNA Interference Works

Our RNAi therapeutics mimic this process by delivering specially designed small interfering RNAs (siRNAs) that, as part of RISC (RNA-induced silencing ...

Effective small interfering RNA design based on convolutional ...

Effective small interfering RNA design based on convolutional neural network. Abstract: In functional genomics, small interfering RNA (siRNA) can be used to ...

Highly Efficient Small Interfering RNA Delivery to Primary ...

Here we show that treatment with vector peptide-linked siRNAs leads to highly efficient induction of RNAi in mammalian neurons cultured from the central and ...

Small Interfering RNA-mediated Silencing Induces Target ...

Gene silencing using small interfering RNA (siRNA) is a valuable laboratory tool and a promising approach to therapeutics for a variety of human diseases.

Small interfering RNA – Knowledge and References - Taylor & Francis

Small interfering RNA [42, 44] (siRNA) is a helix with 20–25 nucleotides that interferes with gene expression through the cleavage of mRNA by a protein/RNA ...

Small interfering RNAs (siRNAs) in cancer therapy: a nano-based ...

In this review, we discuss the progress of siRNA therapy as well as its medical application via nanoparticle-mediated delivery for cancer treatment.

A small interfering RNA (siRNA) database for SARS-CoV-2 | bioRxiv

Beyond target sequences, it also displays more than 170 features, including thermodynamic information, base context, target genes and alignment ...

siRNAs—A New Class of Medicines - JAMA Network

siRNAs—A New Class of Medicines ... Small interfering RNA (siRNA) is one of several nucleic acid molecules representing a third class of ...

Novel Small Interfering RNA–Containing Solution Protecting Donor ...

The ultrasound scans demonstrated that the siRNA-containing solution can partially prevent I/R injury and showed improved heart graft function.

Small interfering RNA (siRNA) - (General Genetics) - Fiveable

Small interfering RNA (siRNA) is a class of double-stranded RNA molecules, typically 20-25 nucleotides in length, that play a crucial role in the regulation of ...

Identification of essential genes in cultured mammalian cells using ...

These short RNA duplexes resemble the processing products from long dsRNAs, and are referred to as small interfering RNAs (siRNAs) (Elbashir et al., 2001b). One ...

Small interfering RNA - Bionity

Small interfering RNA Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, are a class of 20-25 nucleotide-long.

Transgene Silencing, RNA Interference, and the Antiviral Defense ...

In antiviral RNAi, virus infection triggers Dicer processing of virus-specific double-stranded RNA into small interfering RNAs (siRNAs).

Current Transport Systems and Clinical Applications for Small ...

RISC RNA-activated silencing complex, RLC RISC loading complex, RNAi RNA interference, shRNA short hairpin RNA, siRNA small interfering RNA.

Sustained Small Interfering RNA Delivery by Mesoporous Silicon ...

For all of the potential small interfering RNA (siRNA) delivery advantages they engender, nanoparticles also have some limitations including ...