- Trained Immunity as an Adaptive Branch of Innate Immunity🔍
- In Vitro Experimental Model of Trained Innate Immunity in Human ...🔍
- What is Trained Immunity?🔍
- Regulating trained immunity with nanomedicine🔍
- Trained immunity of alveolar macrophages enhances injury ...🔍
- Therapeutic targeting of trained immunity.🔍
- β|glucan|coupled superparamagnetic iron oxide nanoparticles ...🔍
- Trained Immunity in Viral Infections🔍
Small molecules induce trained immunity
Trained Immunity as an Adaptive Branch of Innate Immunity - MDPI
Trained immunity is realized by the epigenetic reprogramming of non-immunocompetent cells, primarily monocytes/macrophages and natural killer (NK) cells.
In Vitro Experimental Model of Trained Innate Immunity in Human ...
Trained immunity was assessed in terms of the secondary cytokine response, the production of reactive oxygen species, cell morphology, and ...
What is Trained Immunity? - News-Medical
A wide range of stimuli, such as beta-glucan (fungal ligand) and BCG (bacillus Calmette–Guérin), are known to induce trained immunity. ... Molecular Immunology.
mRNA can also be delivered to myeloid cells to induce protein expression56,113,114. ... 1), and a wealth of small-molecule inhibitors have been shown to inhibit ...
Trained immunity of alveolar macrophages enhances injury ...
Recent studies suggest that innate immune cells such as monocytes and macrophages also exhibit key features of immune memory and this is ...
Therapeutic targeting of trained immunity. - Abstract - Europe PMC
In this Opinion article, we detail the latest insights on the mechanisms responsible for the induction of trained immunity, including all its relevant molecular ...
β-glucan-coupled superparamagnetic iron oxide nanoparticles ...
BSNP-induced trained immunity protected mice against sepsis caused by E. coli and CLP and also against secondary infection. We found that BSNP treatment ...
Trained Immunity in Viral Infections - Annual Reviews
One of the most important molecular mechanisms for the induction of trained immunity is the epigenetic reprogramming of innate immune cells, ...
Trained Immunity-Based Vaccines: A New Paradigm for the ...
increase immunogenicity of novel vaccine design approaches based on small molecules, like ... induce specific adaptive immunity and non-specific trained immunity ...
Epigenetic and Transcriptional Regulation of Innate Immunity in ...
Similarly, b-glucans induce trained immunity ... Tumor-selective induction of apoptosis and the small-molecule immune response modifier imiquimod.
BCG-induced trained immunity: history, mechanisms and potential ...
Trained immunity has so far shown beneficial effects on cancer, viral-infections, autoimmune diseases, and a variety of other diseases, ...
Epigenetics and Trained Immunity | Antioxidants & Redox Signaling
This biological process of innate immune memory has been called trained immunity (92), and it is illustrated by the observation that stimulation of innate ...
Mihai Netea - Trained immunity: a memory for innate host defense
Keynote lecture by Mihai Netea (Radboud University, The Netherlands) at Optimmunize: Improving the beneficial effects of vaccines 2020 ...
and fungus-derived PAMPs induce innate immune memory via ...
This phenomenon, termed innate immune memory (or trained immunity), can be elicited by exposure to microbes or treatment with pathogen-associated molecular ...
Trained immunity is induced in humans after immunization with ... - JCI
In addition, trained immunity has been shown to increase the ability of myeloid cells to produce IL-1β. For example, human monocytes trained ...
'Trained immunity': consequences for lymphoid malignancies
Recently, it has been shown that cells of the innate immune system, such as monocytes/macrophages and natural killer cells, harbor features of ...
CAR T Cells: Engineering Immune Cells to Treat Cancer - NCI
And not only is the source of T cells and the type of immune cell being reconsidered, but so is where the therapies are actually made. Several ...
Immune System Function, Conditions & Disorders - Cleveland Clinic
Invaders your immune system protects you against include: Bacteria. Viruses. Fungi that can cause infections. Parasites. Cancer cells. How does the immune ...
This triggers our immune system to produce antibodies and activate other immune cells to fight off what it thinks is an infection. This is what ...
a memory for innate host defense" by Dr. Mihai Netea - YouTube
"Trained immunity: a memory for innate host defense" by Dr. Mihai Netea. 4.3K views · 1 year ago ...more ...